Publications by authors named "Audrey Wetzel"
Cancers are consequences of cellular dysfunction leading to an aberrant cellular multiplication and proliferation, subsequently yielding metastasis formation. Inflammatory reaction, with immune cell recruitment, is the main defense against precancerous lesions. However, an inflammatory environment also favors cancer cell progression, with cancer cell evasion from immune surveillance, leading to cancer development.
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- Acute graft-versus-host disease (aGVHD) poses a significant challenge to allogeneic hematopoietic cell transplantation, often triggered by lipopolysaccharides (LPS) from gut bacteria.
- Research in mouse models indicated that ineffective clearance of LPS due to low HDL levels led to increased aGVHD severity.
- Administering HDL from human plasma showed promise in reducing aGVHD mortality and severity by modulating immune responses and lowering inflammation.