Publications by authors named "Audrey Van Heest"
Article Synopsis
- Drug delivery to the esophagus is tough due to low drug availability at the target, prompting a focus on local delivery methods that can enhance effectiveness and reduce side effects.
- New mucoadhesive amphiphilic copolymers have been developed using two synthesis methods, resulting in nanoparticles that self-assemble and can trap high amounts of the cancer drug paclitaxel.
- These paclitaxel-loaded nanoparticles show promising results by effectively entering cancer cells and releasing the drug, demonstrating enhanced adhesion to esophageal tissue compared to traditional delivery methods.
Creating synthetic biomarkers for the development of precision diagnostics has enabled detection of disease through pathways beyond those used for traditional biofluid measurements. Synthetic biomarkers generally make use of reporters that provide readable signals in the biofluid to reflect the biochemical alterations in the local disease microenvironment during disease incidence and progression. The pharmacokinetic concentration of the reporters and biochemical amplification of the disease signal are paramount to achieving high sensitivity and specificity in a diagnostic test.
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