The Role of Vascular Biomarkers in Outcomes of Patients with Kidney Disease.

Background: Vascular biomarkers may explain the link between acute kidney injury (AKI) and poor long-term outcomes such as cardiovascular disease (CVD). Vessel injury is exceedingly common in AKI and contributes to the development of kidney fibrosis and CVD. As prominent determinants of vessel stability in the body, angiopoietins and other prominent vascular biomarkers may explain this biological link.

Honoring the gift: The transformative potential of transplant-declined human organs.

For decades, transplantation has been a life-saving treatment for those fortunate enough to gain access. Nevertheless, many patients die waiting for an organ and countless more never make it onto the waitlist because of a shortage of donor organs. Concurrently, thousands of donated organs are declined for transplant each year because of concerns about poor outcomes post-transplant.

Wanted: An endothelial cell targeting atlas for nanotherapeutic delivery in allograft organs.

Despite the profound shortage of organs available for transplant in the U.S., over 5,000 donated organs were declined for use in 2020.

Correction to: Advanced Modeling to Predict Pneumonia in Combat Trauma Patients.

In the original article, the units indicated on the y-axes of Fig. 3 are incorrectly labelled. The correct label is pg/mL.

Driving biology: The effect of standardized wound management on wound biomarker profiles.

Background: The timing of coverage of an open wound is based on heavily on clinical gestalt. DoD's Surgical Critical Care Initiative created a clinical decision support tool that predicts wound closure success using clinical and biomarker data. The military uses a regimented protocol consisting of serial washouts and debridements.

Advanced Modeling to Predict Pneumonia in Combat Trauma Patients.

Background: Tools to assist clinicians in predicting pneumonia could lead to a significant decline in morbidity. Therefore, we sought to develop a model in combat trauma patients for identifying those at highest risk of pneumonia.

Methods: This was a retrospective study of 73 primarily blast-injured casualties with combat extremity wounds.

Vacuum-assisted vegetation removal with percutaneous lead extraction: a systematic review of the literature.

Purpose: To perform a systematic review of reports in which the AngioVac™ percutaneous vacuum-assisted aspiration system was successfully used to debulk or remove vegetations prior to percutaneous lead extraction.

Methods: We included all studies and case reports that used a percutaneous aspiration technique for vegetation removal or debulking with percutaneous lead extraction for patients with lead-associated endocarditis. Ten reports and retrospective data from our centers were used, which included a total of 88 patients and 205 leads.