Publications by authors named "Audrey Rouaix"
Article Synopsis
- Ricin is a highly toxic substance linked to bioterrorism, and while a vaccine (RiVax™) is in development, no effective treatments currently exist for ricin poisoning.
- * Studies have shown that anti-ricin monoclonal antibodies (mAbs) show great potential for neutralizing ricin and protecting against its effects in animal models.
- * One specific mAb, RicE5, demonstrated over 90% survival in mice after ricin exposure, even when administered 6 hours or, to a lesser extent, 24 hours post-exposure, suggesting strong therapeutic potential and long-term immunity.
Article Synopsis
- Ricin is a highly toxic protein and potential biowarfare agent with no approved specific treatment available.
- Antibodies have been explored for protection, but their effectiveness may vary against different ricin isoforms (D and E) due to high specificity.
- This study found that certain antibodies have varied neutralizing effects depending on the ricin variant and that a combination of specific antibodies can significantly enhance protective outcomes in mouse models.
Salmonella and Shigella species are food- and water-borne pathogens that are responsible for enteric infections in both humans and animals and are still the major cause of morbidity and mortality in the emerging countries. The existence of multiple Salmonella and Shigella serotypes as well as the emergence of strains resistant to antibiotics require the development of broadly protective therapies. Those bacteria utilize a Type III Secretion System (T3SS), necessary for their pathogenicity.
View Article and Find Full Text PDFBackground: Salmonella enterica species are enteric pathogens that cause severe diseases ranging from self-limiting gastroenteritis to enteric fever and sepsis in humans. These infectious diseases are still the major cause of morbidity and mortality in low-income countries, especially in children younger than 5 years and immunocompromised adults. Vaccines targeting typhoidal diseases are already marketed, but none protect against non-typhoidal Salmonella.
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