Is radiological evaluation as good as computer-based volumetry to assess hippocampal atrophy in Alzheimer's disease?

Introduction: Hippocampus volumetry is a useful surrogate marker for the diagnosis of Alzheimer's disease (AD). Our purpose was to compare visual assessment of medial temporal lobe atrophy made by radiologists with automatic hippocampal volume and to compare their performances for the classification of AD, mild cognitive impairment (MCI) and cognitively normal (CN).

Methods: We studied 30 CN, 30 MCI and 30 AD subjects.