Publications by authors named "Audrey Lie"
Nat Biotechnol
October 2024
Article Synopsis
- Current chromatin analysis methods struggle with complex tissues, prompting the development of Droplet Hi-C, a new technique using microfluidics for high-throughput, single-cell profiling.
- Droplet Hi-C allowed researchers to map chromatin structures in mouse cortex and assess gene regulation in various cortical cell types, as well as identify genetic changes in human cancers.
- The technique also combines chromatin and transcriptome profiling in single cells, improving insights into the relationship between chromatin architecture and gene expression in both healthy and tumor tissues.*
