Publications by authors named "Audrey Dejong"
ACS Infect Dis
November 2022
Article Synopsis
- SARS-CoV-2, the virus responsible for the COVID-19 pandemic, binds to human cells through its spike protein interacting with the ACE2 receptor; blocking this interaction is key to preventing infection.
- Researchers optimized an AlphaLISA assay to study the binding of the SARS-CoV-2 spike protein (S-614G variant) to ACE2 and screened over 30,000 compounds for potential inhibitors.
- Two effective compounds, oleic acid and suramin, were found to inhibit the interaction between S-614G and ACE2, with oleic acid showing stronger effects, highlighting the importance of using the full-length spike protein for identifying binding inhibitors.
