Vibration-Controlled Transient Elastography-Based Parameters Predict Clinical Outcomes in Liver Transplant Recipients.

Background And Aims: Vibration-controlled transient elastography (VCTE) is used in clinical practice to risk-stratify liver transplant (LT) recipients; however, there are currently little data demonstrating the relationship between VCTE and clinical outcomes.

Methods: A total of 362 adult LT recipients with successful VCTE examination between 2015 and 2022 were included. Presence of advanced fibrosis was defined as liver stiffness measurement (LSM) ≥10.

Development of Clinical Algorithm Utilizing Vibration-Controlled Transient Elastography to Detect Advanced Hepatic Fibrosis in Liver Transplant Recipients.

Introduction: Vibration-controlled transient elastography (VCTE) based liver stiffness measurement (LSM) is an excellent 'rule-out' test for advanced hepatic fibrosis in liver transplant (LT) recipients, however, its ability to 'rule-in' the disease is suboptimal. The study aimed to improve diagnostic performance of LSM in LT recipients.

Methods: Adult LT recipients with a liver biopsy and VCTE were included (N = 150).

myocarditis: a rare but potential sequelae of .

Myocarditis is an inflammatory cardiomyopathy with a diverse range of both infective and non-infective causes. It is an important cause of dilated cardiomyopathy worldwide, with a variable clinical course ranging from a mild self-limiting illness to fulminant cardiogenic shock requiring mechanical circulatory support and cardiac transplantation. Here, we describe a case of acute myocarditis secondary to infection in a man in his 50s who presented with an acute coronary syndrome following a recent gastrointestinal illness.

Global Variability in Administrative Approval Prescription Criteria for Biologic Therapy in Severe Asthma.

Background: Regulatory bodies have approved five biologics for severe asthma. However, regional differences in accessibility may limit the global potential for personalized medicine.

Objective: To compare global differences in ease of access to biologics.

Avoiding surveillance biopsy: Use of a noninvasive biomarker assay in a real-life scenario.

Purpose: TruGraf™ blood test measures a specific gene expression signature in peripheral blood mononuclear cells for noninvasive assessment of kidney transplant recipients (KTRs) with stable renal function, excluding subclinical acute rejection (subAR) with high degree of confidence. Study objective was to correlate TruGraf™ test with 6-month surveillance biopsy (SBx).

Methods: Prospective, single-center study of 116 consecutive KTRs with SBx performed at 6 months post-transplant.