Publications by authors named "Audree Lemieux"
Article Synopsis
- - T cell immune dysfunction is a significant issue in chronic HIV infection, and evaluating this dysfunction requires a method that involves both general and specific activation of T cells.
- - Researchers developed a tunable artificial antigen-presenting cell (aAPC) system using silica microbeads, which showed that adding CD28 co-stimulation to anti-CD3 enhances T cell activation and cytokine production, especially IL-2.
- - CD4 and CD8 T cells from untreated HIV patients displayed altered immune responses with a reduced dependence on CD28, and while antiretroviral therapy helps restore some functions in CD4 T cells, CD8 T cells remain impaired, suggesting persistent dysfunction linked to HIV.
Broadly applicable methods to identify and characterize antigen-specific CD4 and CD8 T cells are key to immunology research, including studies of vaccine responses and immunity to infectious diseases. We developed a multiplexed activation-induced marker (AIM) assay that presents several advantages compared to single pairs of AIMs. The simultaneous measurement of four AIMs (CD69, 4-1BB, OX40, and CD40L) creates six AIM pairs that define CD4 T cell populations with partial and variable overlap.
View Article and Find Full Text PDFThe host spectrum of viruses is quite diverse, as they can sustainedly infect a few species to several phyla. When confronted with a new host, a virus may even infect it and transmit sustainably in this new host, a process called 'viral spillover'. However, the risk of such events is difficult to quantify.
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