OPPORTUNISTIC ASSESSMENT OF CARDIOVASCULAR RISK USING AI-DERIVED STRUCTURAL AORTIC AND CARDIAC PHENOTYPES FROM NON-CONTRAST CHEST COMPUTED TOMOGRAPHY.

Background: Primary prevention of cardiovascular disease relies on accurate risk assessment using scores such as the Pooled Cohort Equations (PCE) and PREVENT. However, necessary input variables for these scores are often unavailable in the electronic health record (EHR), and information from routinely collected data (e.g.

Effects of Pitavastatin on Coronary Artery Disease and Inflammatory Biomarkers in HIV: Mechanistic Substudy of the REPRIEVE Randomized Clinical Trial.

Importance: Cardiovascular disease (CVD) is increased in people with HIV (PWH) and is characterized by premature noncalcified coronary plaque. In the Randomized Trial to Prevent Vascular Events in HIV (REPRIEVE), pitavastatin reduced major adverse cardiovascular events (MACE) by 35% over a median of 5.1 years.