MCR-1 and OXA-48 Acquisition in KPC-Producing Escherichia coli after Colistin Treatment.

The spread of -encoding plasmids into carbapenem-resistant raises concerns about the emergence of untreatable bacteria. We report the acquisition of in a carbapenem-resistant strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the carbapenemase-producing strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 -encoding plasmid.