Reliable assessment of the incidence of childhood autoimmune hemolytic anemia.

Background: Childhood autoimmune hemolytic anemia (AIHA) is a rare and severe disease characterized by hemolysis and positive direct antiglobulin test (DAT). Few epidemiologic indicators are available for the pediatric population. The objective of our study was to reliably estimate the number of AIHA cases in the French Aquitaine region and the incidence of AIHA in patients under 18 years old.

Fibrates and risk of cancer in tissues with high PPAR-α concentration: a nested case-control study.

Background: Fibrates are lipid-lowering agents that act as peroxisome proliferator-activated receptor (PPAR)-α agonists. They have been associated with cancers in experimental models, but data in humans are rare, and among published studies none has investigated cancers in tissues with high PPAR-α concentrations.

Methods: A nested case-control study was performed in a French population-based healthcare database.

Validity of a traffic air pollutant dispersion model to assess exposure to fine particles.

Introduction: Fine particles (PM(2.5)) are an important component of air pollution. Epidemiological studies have shown health effects due to ambient air particles, particularly allergies in children.