Publications by authors named "Aude E Duquesne"
Article Synopsis
- Superoxide dismutase 1 (SOD1) is an enzyme that protects cells from damage caused by reactive oxygen species, and its activation relies on copper, which is delivered by the copper chaperone CCS.
- The interaction between PDZ2alpha, a domain of the neuronal adaptor protein X11alpha, and CCS impairs the copper insertion into apo-SOD1, affecting its function.
- Research has identified that PDZ2alpha binds specifically to a four-amino-acid sequence (PAHL) from CCS, with the C-terminal leucine being crucial for this interaction, which is essential for understanding the mechanisms of SOD1 activation.
