Publications by authors named "Aude Aline-Fardin"

Article Synopsis
  • Intracardiac masses, like myxomas, can sometimes be identified following a stroke, but distinguishing them through echocardiography can be challenging.
  • A case study involved a 58-year-old man with various health issues who suffered an ischemic stroke; his echocardiogram showed a large mass in the left atrium, leading to a diagnosis of myxoma after surgery.
  • Myxomas may not show symptoms for a long time and can be linked to embolic complications, emphasizing the need for a comprehensive, team-based management approach.
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Purpose: Managing high-grade endometrial cancer in Martinique poses significant challenges. The diversity of copy number alterations in high-grade endometrial tumors, often associated with a TP53 mutation, is a key factor complicating treatment. Due to the high incidence of high-grade tumors with poor prognosis, our study aimed to characterize the molecular signature of these tumors within a cohort of 25 high-grade endometrial cases.

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Erythroblastic sarcoma (ES) (previously called chloroma or granulocytic sarcoma) are rare hematological neoplams characterized by the proliferation of myeloid blasts at extramedullary sites, and primarily involve the skin and soft tissue of middle-aged adults. ES may be concomitant with or secondary to myeloid neoplasms (mostly acute myeloid leukemia (AML)) or in isolated cases (de novo) without infiltration of the bone marrow by blasts. ES share cytogenetic and molecular abnormalities with AML, including RUNX1T1 fusions.

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  • Pilocytic astrocytomas (PA) are tumors that have unique features based on where they are located in the brain or spine.
  • Doctors face challenges in telling PAs apart from similar tumors, especially in the brain's hemispheric region.
  • A study looked at different types of PAs, and found that they often affect kids and can show various patterns in medical tests, highlighting the need for careful examination for accurate diagnosis.
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Introduction: Endometriosis is a female disease that affects 5-10% of women of childbearing age, with predominantly pelvic manifestations. It is currently declared as a public health priority in France. Thoracic endometriosis syndrome (TES) is the most common extra-pelvic manifestation.

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  • Histoplasmosis, caused by the fungus Histoplasma capsulatum, is reported in Martinique, especially in immunosuppressed individuals or those with significant exposure, but acute cases in healthy individuals are uncommon.
  • A series of 4 cases of acute pulmonary histoplasmosis was identified in immunocompetent patients, with one having confirmed exposure and three with potential exposure, where diagnoses were based on microbiological and histological findings.
  • All patients received itraconazole treatment for 3 months and improved; this raises concerns about hidden exposure in the Caribbean, highlighting the need for increased awareness and caution in the French West Indies and French Guiana.
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To describe survival according to prognostic factors of women with breast cancer in French overseas territory (Martinique) during 2008-2017. We performed a Cox model for prognostic factors for OS in breast cancer patients. The cut-off date for the analysis was 13/10/2018.

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Targetable kinase fusions are extremely rare (<1%) in colorectal cancers (CRCs), making their diagnosis challenging and often underinvestigated. They have been shown particularly frequently among MSI-High, BRAF/KRAS/NRAS wild-type CRCs with MLH1 loss (MLH1 MSI-High wild-type). We searched for NTRK1, NTRK2, NTRK3, ALK, ROS1, BRAF, RET, and NRG1 kinase fusions in CRCs using methods easy-to-implement in pathology laboratories: immunohistochemistry (IHC), fluorescent in situ hybridization (FISH), and fully automated real-time PCR targeted analyses.

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Background: Cooperation in public health and in oncology in particular, is currently a major issue for the island of Martinique, given its geopolitical position in the Caribbean region. The region of Martinique shares certain public health problems with other countries of the Caribbean, notably in terms of diagnostic and therapeutic management of patients with cancer. We present here a roadmap of cooperation priorities and activities in cancer surveillance and oncology in Martinique.

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Context: Extra-gastrointestinal stromal tumors (E-GIST) presenting in the liver are exceedingly rare and raise difficult diagnostic and therapeutic challenges.

Methods: We report on two cases of liver E-GIST with different clinical presentations. We describe their clinical and imaging features, their histopathological and molecular characteristics, their treatment and their course.

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Introduction: Lung cancer is the leading cause of cancer deaths in the United States and worldwide. Biomarker testing is critical to personalized therapy in lung adenocarcinoma and has been extensively investigated in whites and Asians. However, little information addresses the underlying genetic changes among Caribbean and African Caribbean patients.

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Crystal-storing histiocytosis (CSH) is a rare complication of monoclonal gammopathies caused by accumulation of crystalline material inside macrophages, and it may result in a variety of clinical manifestations depending on the involved organs. Although immunoglobulin κ light chains (LCs) seem to be the most frequent pathogenic component, very few molecular data are currently available.A 69-year-old man presented with a very poor performance status.

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Chronic CD8(+) T-cell expansions can result in parotid gland swelling and other organ infiltration in HIV-infected patients, or in persistent cytopenias. We report 14 patients with a CD8+ T-cell expansion to better characterize the clinical spectrum of this ill-defined entity. Patients (9 women/5 men) were 65 year-old (range, 25-74).

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