Publications by authors named "Aubrey Smartt"
The role of SPARC in the in vivo lung response to crocidolite asbestos was addressed by instillation of crocidolite asbestos in a series of wild-type or SPARC-null mice. Animals were sacrificed at one week, one month, and three months post-instillation to assess the impact of SPARC on multiple stages in the development of fibrosis. RNA was harvested from 10 animals/time point, pooled, and used to probe a mouse array containing approximately 10,000 probes.
View Article and Find Full Text PDFLibby, MT is the site of a closed vermiculite mine that produced ore contaminated with asbestos-like amphiboles. Worldwide distribution of the material and the long latency period for manifestation of asbestos-related diseases (ARDs) has created a significant health threat for many years to come. The composition of the Libby material [termed the Libby amphibole (LA)] differs from other well-studied types of asbestos in that it is a mixture of several amphibole fibers.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how exposure to amphibole-contaminated vermiculite from Libby, MT, may lead to asbestos-related diseases using a mouse model.
- Mice were exposed to different types of asbestos, and their lung tissues were analyzed six months later to assess gene expression changes.
- The researchers used an analysis program to categorize altered genes, aiming to enhance the understanding of how asbestos impacts genetic response pathways.