Publications by authors named "Aubrey M Sosibo"
Background: Prediabetes is a condition that often precedes the onset of type 2 diabetes mellitus (T2DM). Literature evidence indicates that prediabetes is reversible, making it an important therapeutic target for preventing the progression to T2DM. Several studies have investigated intermittent fasting as a possible method to manage or treat prediabetes.
View Article and Find Full Text PDFBackground: A high-calorie diet results in the development of prediabetes (PD) or type 2 diabetes mellitus (T2DM). This diet has been reported to cause changes in microbial composition, concentration levels of glycemic parameters, and immune cells or inflammatory cytokines. This systematic review and meta-analysis aimed to evaluate the effects of prebiotics, as well as Mediterranean and plant-based dietary interventions, on gut microbiota composition and glucose homeostasis in individuals with PD or T2D.
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- - The study highlights the rising prevalence of pre-diabetes in urban areas, particularly among individuals aged 25-45, and aims to explore immune response changes linked to the condition in Durban, South Africa.
- - Blood samples from patients were categorized into non-diabetic, pre-diabetic, and type 2 diabetic groups, revealing increased eosinophil and basophil levels, as well as elevated serum inflammatory markers in pre-diabetic and diabetic patients compared to non-diabetics.
- - The research indicates that pre-diabetes triggers immune activation, prompting calls for further studies with more diverse and larger sample sizes to better understand these immune responses based on gender representations.
Article Synopsis
- The study aimed to investigate the prevalence of pre-diabetes among participants aged 25-45 in Durban, South Africa, as this condition has been largely underexplored in research.
- Using a retrospective design, researchers collected fasting blood samples from patients without a diabetes diagnosis and confirmed pre-diabetes using established criteria from the ADA and WHO, stratifying results by age, gender, and ethnicity.
- The findings indicated a concerning average prevalence of 68% for pre-diabetes, with the highest rates (83%) using the IFG criterion, particularly affecting the Indian ethnic group, suggesting urgent need for preventive measures against the progression to Type 2 Diabetes Mellitus.
: Pre-diabetes is an intermediate, asymptomatic state between normoglycaemia and the onset of type 2 diabetes mellitus (T2D). Recent reports indicate that there are sub-clinical changes observed in red blood cells during pre-diabetes. This systematic review protocol will provide an outline of all procedures in the synthesis of the available data on the changes in red blood cell indices.
View Article and Find Full Text PDFBackground: Pre-diabetes is an intermediate state between normoglycaemia and type 2 diabetes (T2D). This condition has been shown to be asymptomatic thus making it hard to investigate the changes that occur in the body during this state. Recent findings stipulate that in this state, there are changes that are often associated with T2D.
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- Pre-diabetes is a condition indicating an increased risk of developing type 2 diabetes, and this study aims to systematically review and analyze the prevalence of pre-diabetes in South Africa to generate accurate estimates.
- A literature search covering studies from 2000 to 2020 identified 13 eligible studies, revealing a pre-diabetes prevalence rate of 15.56% in the South African population, with common correlates being hypertension, obesity, and a sedentary lifestyle.
- The results underscore a significant public health concern regarding pre-diabetes in South Africa and suggest a need for further research into its underlying factors.
Background: Prediabetes is an asymptomatic, intermediate state between normoglycemia and the onset of type 2 diabetes mellitus. Recent reports indicate that during prediabetes, there are subclinical changes to immune cells and inflammatory markers. Therefore, this systematic review will provide a synthesis of the available data on the changes in the concentration of immune cells and selective inflammatory markers.
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- Pre-diabetes is a condition that signals an increased risk for developing diabetes and other metabolic issues, and this study aims to create a systematic review on its prevalence in South Africa.
- The researchers will analyze various studies published from 2000 to 2020 to gather data on pre-diabetes rates and identify any factors that may contribute to differences in findings.
- Since the study will use non-identifiable data, no ethics approval is needed, and the results are expected to enhance understanding of pre-diabetes in South Africa.
Pre-diabetes and COVID-19, could we be missing the silent killer?
Exp Biol Med (Maywood)
February 2021