Publications by authors named "Aubrey M Smartt"
Article Synopsis
- The study investigated how SPARC influences lung responses to crocidolite asbestos using wild-type and SPARC-null mice, examining changes at one week, one month, and three months post-exposure.
- At one week, gene expressions related to immune response and energy usage were significantly altered, while later stages showed changes in genes connected to protein degradation and signaling pathways, particularly Wnt signaling.
- The Wnt pathway, which is associated with bone growth and fibroblast activity, is notably regulated by SPARC, suggesting its critical role in asbestos-induced lung fibrosis.
Libby, MT is the site of a closed vermiculite mine that produced ore contaminated with asbestos-like amphiboles. Worldwide distribution of the material and the long latency period for manifestation of asbestos-related diseases (ARDs) has created a significant health threat for many years to come. The composition of the Libby material [termed the Libby amphibole (LA)] differs from other well-studied types of asbestos in that it is a mixture of several amphibole fibers.
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