Publications by authors named "Aubrey E McDermott"
Article Synopsis
- Interstitial stromal cells are essential for muscle development and repair, with specific expression of Hoxa11 and Hoxd11 important for muscle patterning during embryonic stages.
- Hoxa11-CreERT2 lineage tracing shows these cells contribute to muscle fibers in adulthood, surpassing contributions from traditional satellite cells.
- Isolated Hoxa11-expressing interstitial cells cannot form myotubes on their own, but can assist in the differentiation of myotubes, indicating they act as muscle progenitors rather than stem cells.
genes encode transcription factors that are critical for embryonic skeletal patterning and organogenesis. The , , and paralogs are expressed in the lung mesenchyme and function redundantly during embryonic lung development. Conditional loss-of-function of these genes during postnatal stages leads to severe defects in alveologenesis, specifically in the generation of the elastin network, and animals display bronchopulmonary dysplasia (BPD) or BPD-like phenotype.
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