Publications by authors named "Aubrey C Annis"
Article Synopsis
- Persistent opioid use after surgery increases the risk of opioid use disorder, overdose, and death, but the genetic factors behind this issue were largely unknown.
- A study with around 40,000 participants identified some genetic signals associated with persistent opioid use, particularly focusing on the OPRM1 gene, where two variants showed significant results.
- The findings strengthen the link between opioid dependence and addiction, but the lack of consistent associations in other genes questions the reliability of previous studies.
Population-scale biobanks linked to electronic health record data provide vast opportunities to extend our knowledge of human genetics and discover new phenotype-genotype associations. Given their dense phenotype data, biobanks can also facilitate replication studies on a phenome-wide scale. Here, we introduce the phenotype-genotype reference map (PGRM), a set of 5,879 genetic associations from 523 GWAS publications that can be used for high-throughput replication experiments.
View Article and Find Full Text PDFThe Genes for Good study uses social media to engage a large, diverse participant pool in genetics research and education. Health history and daily tracking surveys are administered through a Facebook application, and participants who complete a minimum number of surveys are mailed a saliva sample kit ("spit kit") to collect DNA for genotyping. As of March 2019, we engaged >80,000 individuals, sent spit kits to >32,000 individuals who met minimum participation requirements, and collected >27,000 spit kits.
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