Publications by authors named "Aubert H"
Background: Patients with atopic dermatitis (AD) may discontinue dupilumab owing to dupilumab-induced ocular adverse events (DOAEs) or dupilumab-induced facial redness (DFR).
Objective: To evaluate DOAE and DFR outcomes after switching to tralokinumab or Janus kinase inhibitor (JAKi).
Methods: This retrospective study included 106 patients discontinuing dupilumab because of DOAEs and/or DFR.
Rationale: Sirolimus is a treatment for slow-flow vascular malformations (SFVMs). However, the long-term management remains challenging.
Objectives: The SIROLO study assessed the long-term effects and real-life management of oral sirolimus for SFVMs by investigating data from 15 French tertiary centres for vascular anomalies.
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- Toe-web (TW) intertrigo is a painful skin condition primarily caused by Gram-negative bacteria, often accompanied by eczema, which can lead to significant functional disability.
- A study was conducted to assess the effectiveness of a standardized treatment plan using topical corticosteroids over a 6-month follow-up for patients with GNB-TW intertrigo.
- Results showed no significant difference in disease duration between patients treated with the standardized plan and those treated without it, but relapses were less frequent in the standardized cohort.
Background: New highly effective drugs for moderate-to-severe cutaneous psoriasis are regularly marketed, and the hierarchy of treatments thus requires frequent review.
Objectives: A Delphi method was used to enable a structured expert consensus on the use of systemic treatments and phototherapy among adults with moderate-to-severe psoriasis.
Methods: The Delphi method consists in achieving a convergence of opinions among a panel of experts using several rounds of questionnaires with controlled feedback between rounds.
Article Synopsis
- The study explores the effectiveness of one-on-one, nurse-led therapeutic patient education (TPE) for children with moderate-to-severe atopic dermatitis (AD), pitting it against standard care alone.
- A total of 176 children participated, but by week 24, there was no significant difference in disease control (measured by the SCORAD index) between the two groups.
- The only notable improvement from the TPE was a reduction in fear of using topical steroids, although the intervention group displayed consistently lower disease severity throughout the study.
Article Synopsis
- The study aimed to clarify the dermatological features of Costello syndrome (CS) and distinguish them from other similar syndromes like cardiofaciocutaneous syndrome (CFCS) and types of Noonan syndrome (NS).
- A ten-year multi-center study involving 31 patients found common skin and hair anomalies in CS, such as excessive eyebrows and various types of skin growths, which can help differentiate CS from CFCS and NS.
- The findings propose multiple melanocytic naevi as a potential marker for a milder form of CS and suggest that acitretin could be beneficial for treating certain skin conditions, although no clear genotype-phenotype link was identified.
Blood filtration using micro-fabricated devices is an interdisciplinary topic of research and innovation driven by clinical applications in cytapheresis, cardiovascular disease monitoring, or liquid biopsy. In this paper, we demonstrate that a micro-perforated membrane can be equipped with sensing microelectrodes for detecting, in situ and in real-time, the capture of cellular material during ex vivo filtration of whole blood under high flow rates. This work describes the fabrication process of the sift and detection microdevice.
View Article and Find Full Text PDFThe Patient-Oriented Scoring of Atopic Dermatitis and SCORAD in young children: New data on interpretability and clinical usefulness.
J Eur Acad Dermatol Venereol
January 2024
Background: There is limited data about the clinical meaningfulness of the Scoring of Atopic Dermatitis (SCORAD) and Patient-Oriented SCORAD (PO-SCORAD), particularly in children with mild-to-moderate AD. Regular use of patient-reported outcomes, may deliver more accurate information about the overall health status of AD patients than routine but sparse physician assessments.
Objective: To confirm the correlation between SCORAD, PO-SCORAD, Patient-Oriented Eczema Measure (POEM) and Investigator's Global Assessment (IGA).
In this paper, a neural network approach is applied for solving an electromagnetic inverse problem involving solid dielectric materials subjected to shock impacts and interrogated by a millimeter-wave interferometer. Under mechanical impact, a shock wave is generated in the material and modifies the refractive index. It was recently demonstrated that the shock wavefront velocity and the particle velocity as well as the modified index in a shocked material can be remotely derived from measuring two characteristic Doppler frequencies in the waveform delivered by a millimeter-wave interferometer.
View Article and Find Full Text PDFBackground: Low-flow malformations (LFMs) are rare diseases with a significant impact on health-related quality of life (HRQoL), especially in children. No disease-specific questionnaire is available for children with LFMs.
Objective: To develop and validate a specific HRQoL questionnaire for children from 11 to 15 years old suffering from LFMs.
Article Synopsis
- * Research involving gene expression profiling of skin biopsies from DI-Pso patients revealed significant activation of the T helper 17/IL-23 pathways, alongside increased IL-36 expression, which is a marker of pustular psoriasis.
- * The findings indicate a shift in immune response from T helper 2 to T helper 17 in DI-Pso cases, coupled with notable skin barrier dysfunction compared to healthy individuals and those with other skin conditions.
Blast waves generated by energetic materials involve very fast time variations in the pressure. One important issue for blast wave metrology is the accurate measurement (typical precision in the range of ±5% or better) of the static overpressure peak. For most near field configurations, this measurement requires ultra-fast sensors with response times lower than a few microseconds.
View Article and Find Full Text PDFRisk of melanoma in congenital melanocytic nevi of all sizes: A systematic review.
J Eur Acad Dermatol Venereol
January 2023
Congenital melanocytic nevi (CMN) are commonly encountered benign skin lesions in newborns. Larger CMN is associated with a higher lifetime risk of developing melanoma. However, the level of risk is unclear when CMN are small or medium-sized.
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- - Combined therapies in treating childhood psoriasis involve using multiple drugs to enhance effectiveness and minimize side effects, with a study evaluating their use in 170 children across France and Italy.
- - Out of the participants, 13% received various combinations of conventional and biologic medications, achieving significant improvements in psoriasis scores, despite reporting a few serious adverse events with positive outcomes.
- - A survey of 61 dermatologists revealed that 64% have used or intend to use these combined therapies, primarily to boost the effectiveness of biologic treatments when initial results are insufficient.
Background: Dupilumab is the first biotherapy available for the treatment of moderate-to-severe childhood atopic dermatitis (AD).
Objective: The aim of this study was to evaluate the effectiveness and safety of dupilumab in daily practice.
Methods: Patients aged 6-11, who had received a first dose of dupilumab, were included in this multicentre retrospective cohort study.
New broadband (>1 MHz) pressure sensors are regularly reported in the literature to measure the overpressure of blast waves. However, the frequency bandwidth needed to accurately measure such overpressure has not yet been clearly discussed. In this article, we present a methodology to determine the bandwidth required to estimate the overpressure magnitude at the front of a blast wave, in order to obtain a desired estimation accuracy.
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- Biological therapies are effective for treating severe psoriasis in children under 12, but this age group is often not included in clinical trials.
- The 'BiPe Jr' study analyzed data from 82 children in France and Italy who received biological treatments, showcasing significant improvement in psoriasis severity and treatment duration for drugs like adalimumab and ustekinumab.
- Although 52 children stopped their treatments mostly due to ineffectiveness and remission, the study pointed out safety concerns with reports of serious adverse events, including severe infections.
PIK3CA-related overgrowth spectrum (PROS) includes rare genetic conditions due to gain-of-function mutations in the PIK3CA gene. There is no approved medical therapy for patients with PROS, and alpelisib, an approved PIK3CA inhibitor in oncology, showed promising results in preclinical models and in patients. Here, we report for the first time the outcome of two infants with PROS having life-threatening conditions treated with alpelisib (25 mg) and monitored with pharmacokinetics.
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