Publications by authors named "Auberi Henry"
Stiffening of the vascular network is associated with the early stages of vascular aging, leading to cardiovascular disorders (hypertension), renal failures, or neurodegenerative diseases (Alzheimer's). Unfortunately, many people remain undiagnosed because diagnostic methods are either unsuitable for a large population or unfamiliar to clinicians which favor the hypertension evaluation. In preclinical research, stiffness studies are often partially conducted.
View Article and Find Full Text PDFBackground: Ovarian cancer (OC) remains one of the most challenging and deadly malignancies facing women today. While PARP inhibitors (PARPis) have transformed the treatment landscape for women with advanced OC, many patients will relapse and the PARPi-resistant setting is an area of unmet medical need. Traditional immunotherapies targeting PD-1/PD-L1 have failed to show any benefit in OC.
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- Type 2 diabetes (T2D) is a significant public health crisis, leading to 6.7 million premature deaths in 2022 due to cardiovascular complications, which are greatly intensified by the disease.
- The study investigates the aging process of the extracellular matrix (ECM) in diabetic mice, revealing that their aorta shows signs of premature aging similar to older, nondiabetic mice, particularly regarding collagen and elastic fiber degradation.
- Findings suggest that these premature changes in the ECM contribute to vascular rigidity, increasing the likelihood of serious conditions like hypertension and atherosclerosis, which may explain the heightened risk of cardiovascular disease and early mortality in T2D patients.
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- Cardiovascular diseases are on the rise globally, largely due to an aging population, leading to significant changes in the structure and function of blood vessels.
- With age, elastic fibers in arteries break down, releasing elastin-derived peptides (EDPs), which can contribute to various vascular and metabolic issues like atherosclerosis and type 2 diabetes.
- The elastin receptor complex (ERC) plays a key role in mediating the biological effects of EDPs, and recent research highlights its composition, signaling pathways, and potential therapeutic strategies aimed at targeting ERC activation.
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- Desialylation, related to sialidases, plays a role in various human disorders, and inhibiting these enzymes might help manage conditions like atherosclerosis.
- In this study, researchers examined the effects of oseltamivir phosphate, a sialidase inhibitor, on atherosclerosis and potential liver toxicity in mice with a high-fat diet.
- Results showed a reduction in LDL cholesterol and aortic elastin fragmentation, but no impact on atherosclerotic plaque size or thrombosis, and it caused negative liver effects, increasing inflammation and fibrosis markers.
Article Synopsis
- - Arterial stiffness, which increases with age and is linked to various cardiovascular diseases, involves changes in the structural proteins elastin and collagen within the aortic tree.
- - The study uses advanced atomic force microscopy to analyze the morphology and elasticity of aorta cross sections from mice of different ages, revealing that the elasticity of both elastic fibers and surrounding areas significantly declines with aging.
- - These findings provide a novel perspective on how aging affects arterial stiffness at the molecular level, suggesting that similar techniques could be useful for studying diseases like atherosclerosis and diabetes, where elastic fibers are damaged.
The Cardiovascular Continuum describes a sequence of events from cardiovascular risk factors to end-stage heart disease. It includes conventional pathologies affecting cardiovascular functions such as hypertension, atherosclerosis or thrombosis and was traditionally considered from the metabolic point of view. This Cardiovascular Continuum, originally described by Dzau and Braunwald, was extended by O'Rourke to consider also the crucial role played by degradation of elastic fibers, occurring during aging, in the appearance of vascular stiffness, another deleterious risk factor of the continuum.
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