Maintenance of the rate of stair use over a long-term period using a stair climbing campaign.

Objective: This study was a long-term survey of a stair climbing campaign that made use of point-of-choice prompts aimed at achieving exemplary behavior in citizens.

Methods: The campaign began in September 2007 at the Kochi Prefectural Office. We monitored office workers who climbed the stairs or used the elevator in the prefectural office building, excluding weekends, from August 2007 through February 2009.

A prospective observational study to examine the relationship between quality of life and adverse events of first-line chemotherapy plus cetuximab in patients with KRAS wild-type unresectable metastatic colorectal cancer: QUACK Trial.

We have planned a multicentre prospective study to examine the relative impact of the efficacy and adverse events of cetuximab plus first-line chemotherapy on the quality of life in Japanese patients with KRAS wild-type unresectable colorectal cancer. The Dermatology Life Quality Index and the European Organization for Research Treatment of Cancer Quality of Life Questionnaire Core 30 will be used to assess dermatology-specific and health-related quality of life. The severity of adverse events will be assessed by using the National Cancer Institute Common Terminology Criteria for adverse Events ver.

Changing behavioral patterns to promote physical activity with motivational signs.

Objectives: We have evaluated the effectiveness of motivational signs in promoting stair use instead of escalators, in terms of gender and age, at a train station with a 37-step staircase. We also examined whether a newspaper article, or booster, had any effect on augmenting the impact of the signs.

Methods: In a serial cross-sectional survey with prompted signs, the subjects were coded by gender and age (over 65 years, under 65 years), and students (13-18 years old and school uniforms).

The weight-bearing rate on the paretic limb of cerebrovascular hemiplegic patients necessary for an independent obstacle negotiation gait.

Purpose: The obstacle negotiation gait (ONG) is a fundamental activity of daily living. In cerebrovascular hemiplegic patients (stroke patients), the weight-bearing rate (WBR) on the paretic limb necessary for an independent ONG was studied.

Methods: One hundred and seventeen stroke patients were involved.

Loss of heterozygosity of the PTH/PTHrP type 1 receptor in oral squamous cell carcinoma.

Parathyroid hormone-related protein (PTHrP) is produced by various types of carcinomas, and is an important factor in the development of bone metastasis. The coexpression of PTHrP and parathyroid hormone/parathyroid hormone-related protein type 1 receptor (PTHR1) in cancer predicts poor patient survival. While genetic transformations of thyroid hormone receptor β (THRβ) have been reported as being associated with reduced survival in patients with oral squamous cell carcinoma (OSCC), the details of transformations in PTHR1 have not been extensively analyzed.

[Promoting daily physical activity by encouraging stair using banners].

Objective: To test the effectiveness of stair-use banners in encouraging the use of stairs instead of escalators.

Design: Observational survey with prompted banners.

Participants: Shoppers and a few employees.

[Controversy of treatment for advanced colorectal cancer--intermedisine].

Until recently, few chemotherapy options were available to treat metastatic colorectalcancer. For years, the standard chemotherapy has been a Fluorouracil (5-FU) alone of 5-FU with leucovorin (LV) modulation. The newer cytotoxic drugs irinotecan (CPT-11) and oxaliplatin (L-OHP) has generated further improvement in survival.