Publications by authors named "Attila L Szvetko"
Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke. Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders. To investigate the role of the homocysteine (Hcy) metabolism pathway in hypertension we conducted a case-control association study of Hcy pathway gene variants in a cohort of Caucasian hypertensives and age- and sex-matched normotensives.
View Article and Find Full Text PDFMultiple sclerosis (MS) is a serious cause of neurological disability among young adults. The clinical course remains difficult to predict, and the pathogenesis of the disease is still modestly understood. Autoimmunity is thought to be a key aspect of the disease, with autoreactive T cells thought to mediate central nervous system (CNS) inflammation to some extent.
View Article and Find Full Text PDFArticle Synopsis
- Multiple sclerosis (MS) is a common neurological disability affecting young adults, typically arising in early to middle adulthood, marked by various neurological symptoms.
- The study focused on two specific variants of the PTPRC gene (C77G and C772T) to determine their potential association with MS in an Australian population, comparing affected individuals with healthy controls.
- Results showed no significant differences in the genetic frequency of these variants between MS patients and controls, indicating that they are not linked to MS susceptibility in this demographic despite the gene's known role in T-cell regulation.