Maximizing solar distillation performance for conical solar still through varied energy storage materials.

The study investigates the performance enhancement of a conical solar distillation system by incorporating different energy storage materials, including glass balls, stainless steel balls, sandstones, and black gravel. These materials were analyzed based on their ability to improve energy and exergy efficiencies. The experimental setup involved using identical sizes (∅ 1.

Unlocking vinpocetine's oncostatic potential in early-stage hepatocellular carcinoma: A new approach to oncogenic modulation by a nootropic drug.

The development of new drugs for the inhibition of hepatocellular carcinoma (HCC) development and progression is a critical and urgent need. The median survival rate for HCC patients remains disappointingly low. Vinpocetine is a safe nootropic agent that is often used to enhance cognitive function.

Hedgehog signaling mastery: R51211's promise in augmenting the therapeutic efficacy of sorafenib.

Sorafenib is a multikinase inhibitor employed for managing hepatocellular carcinoma (HCC). The emergence of sorafenib resistance presents an obstacle to its therapeutic efficacy. One notable approach to overcoming sorafenib resistance is the exploration of combination therapies.

A novel combination therapy targets sonic hedgehog signaling by the dual inhibition of HMG-CoA reductase and HSP90 in rats with non-alcoholic steatohepatitis.

Non-alcoholic steatohepatitis (NASH) is characterized by liver inflammation, fat accumulation, and collagen deposition. Due to the limited availability of effective treatments, there is a pressing need to develop innovative strategies. Given the complex nature of the disease, employing combination approaches is essential.

The role of matrix metalloproteinase-2 and miR-196a2 in bronchial asthma pathogenesis and diagnosis.

Background: Bronchial asthma is a persistent inflammatory respiratory condition that restricts the passage of air and causes hyperresponsiveness. Chronic asthma can be classified into three categories: mild, moderate, and severe. Remodeling took place as the extracellular matrix accumulated in the walls of the airways.

Linagliptin, a DPP-4 inhibitor, activates AMPK/FOXO3a and suppresses NFκB to mitigate the debilitating effects of diethylnitrosamine exposure in rat liver: Novel mechanistic insights.

Accumulating evidence suggests that dysregulation of FOXO3a plays a significant role in the progression of various malignancies, including hepatocellular carcinoma (HCC). FOXO3a inactivation, driven by oncogenic stimuli, can lead to abnormal cell growth, suppression of apoptosis, and resistance to anticancer drugs. Therefore, FOXO3a emerges as a potential molecular target for the development of innovative treatments in the era of oncology.

Itraconazole halts hepatocellular carcinoma progression by modulating sonic hedgehog signaling in rats: A novel therapeutic approach.

Liver cancer stands as the fourth leading global cause of death, and its prognosis remains grim due to the limited effectiveness of current medical interventions. Among the various pathways implicated in the development of hepatocellular carcinoma (HCC), the hedgehog signaling pathway has emerged as a crucial player. Itraconazole, a relatively safe and cost-effective antifungal medication, has gained attention for its potential as an anticancer agent.

Utility of the 4C ISARIC mortality score in hospitalized COVID-19 patients at a large tertiary Saudi Arabian center.

Background: The International Severe Acute Respiratory and Emerging Infections Consortium (ISARIC) 4C mortality score has been used before as a valuable tool for predicting mortality in COVID-19 patients. We aimed to address the utility of the 4C score in a well-defined Saudi population with COVID-19 admitted to a large tertiary referral hospital in Saudi Arabia.

Methods: A retrospective study was conducted that included all adults COVID19 patients admitted to the Armed Forces Hospital Southern Region (AFHSR), between January 2021 and September 2022.

Oxytocin versus a combination of tranexamic acid and ethamsylate in reducing intraoperative bleeding during abdominal myomectomy: a randomized clinical trial.

Objective: Myomectomy is the preferred surgical approach to manage uterine fibroids. However, uterine fibroids are highly vascular tumors and, consequently, extremely susceptible to problems from myomectomy-related hemorrhage. Hence, we aim to compare oxytocin efficacy and safety profile versus tranexamic acid (TA) with ethamsylate for reducing bleeding during myomectomy.

Memantine mitigates ROS/TXNIP/NLRP3 signaling and protects against mouse diabetic retinopathy: Histopathologic, ultrastructural and bioinformatic studies.

Diabetic retinopathy (DRET) triggers vision loss in adults, however, little therapeutic options are existing. Memantine is an anti-Alzheimer drug that antagonizes the activity of glutamate at N-methyl-D-aspartate (NMDA) receptors. Glutamate and thioredoxin-interacting protein (TXNIP) are known to be overexpressed in diabetic retinas and can produce activation of NOD-like receptor protein 3 (NLRP3) with subsequent secretion of interlukin-1β.

Topiramate affords neuroprotection in diabetic neuropathy model via downregulating spinal GFAP/inflammatory burden and improving neurofilament production.

The current study aimed to test the neuroprotective action of topiramate in mouse peripheral diabetic neuropathy (DN) and explored some mechanisms underlying this action. Mice were assigned as vehicle group, DN group, DN + topiramate 10-mg/kg and DN + topiramate 30-mg/kg. Mice were tested for allodynia and hyperalgesia and then spinal cord and sciatic nerves specimens were examined microscopically and neurofilament heavy chain (NEFH) immunostaining was performed.

Hemispherical solar distiller with truncated circular cone-shaped reflector mirrors (TCC-RM): optimum inclination of reflector mirrors.

The present study aims to achieve the highest cumulative yield of the hemispherical distillers, by designing and constructing new reflector mirrors, which are truncated circular cone-shaped reflector mirrors (TCC-RM). To obtain the optimum inclination of TCC-RM that achieves the highest hemispherical distiller's performance, eight inclination angles (10°, 15°, 20°, 25°, 30°, 35°, 40°, and 45° with vertical) were experimentally studied. To achieve this, a series of experimental tests were carried out on the three hemispherical solar distillers: the first represents the reference distiller (traditional hemispherical solar distiller (THSD)) and the other two devices are the hemispherical solar distiller with truncated circular cone-shaped reflector mirrors (HSD-TCCRM) with different inclination angles.

Hemispherical Solar Distiller Performance Utilizing Hybrid Storage Media, Paraffin Wax with Nanoparticles: An Experimental Study.

The traditional method of obtaining fresh water for drinking is by burning fossil fuels, emitting greenhouse gases into the atmosphere. However, renewable energy is gaining more traction since it is available free of cost for producing fresh water. In this study, AlO nanoparticles were distributed in a phase change material (paraffin wax) that had been fixed at a hemispherical distiller water basin.

Programmed death-ligand 1 (PD-L1) polymorphisms as predictive biomarkers for the development of liver cirrhosis and hepatocellular carcinoma in HCV Egyptian patients.

Background: Considering the immune evasion role of programmed death-ligand 1 (PD-L1) in cancer development, its genomic variations might be closely associated with disease development and cancer risks. Accordingly, this study was performed to investigate how the PD-L1 gene polymorphisms affect the susceptibility to hepatitis C virus (HCV)-induced liver cirrhosis and cancer development in the Egyptian population.

Methodology: Two single nucleotide polymorphisms of the PD-L1 gene; rs2297136 (A > G) and rs4143815 (C > G), were studied in 50 HCV, 51 liver cirrhosis, and 52 hepatocellular carcinoma (HCC) patients as well as 50 healthy subjects using real-time PCR.

Energy, exergy, and economic analysis of solar still using coal cylinder fins: an experimental study.

The phenomenon of drinking water scarcity has turned into the foremost issue that the world's populace is facing today. The Algerian desert regions, including the El Oued region (southeastern Algeria), also suffer from drinking water shortages, despite the presence of huge quantities of underground salty water. Solar distillation is among the easy and cheap solutions to solve this problem because this method relies on renewable energy (solar energy) as a key factor in providing drinking water from saltwater.

Ameliorated Stomach Specific Floating Microspheres for Emerging Health Pathologies Using Polymeric Konjac Glucomannan-Based Domperidone.

The goal of this study was to use polymeric konjac glucomannan (KGM), Kollidon VA 64 (KVA64), and glutaraldehyde to ameliorate stomach specific floating microspheres (SSFM) using domperidone (DoN) to increase bioavailability and emerging health pathologies. The SSFM were made using the emulsion cross-linking process, and the polymer was chosen based on its ability to get cross-linked. The thermodynamic parameters were used to determine the A classes of phase solubility curves using ideal complexes produced with KVA64.

Experimental investigation on a modified design of hemispherical solar distiller with v-corrugated iron trays and wick materials for improving freshwater production.

The low energy efficiency of the solar distillers is one of the key barriers to their effectual usage in the desalination domain. Hence, this work introduces an experimental investigation to enhance the freshwater productivity of the hemispherical solar distiller with different trays' configurations and utilizing wick materials. This was achieved by utilizing iron trays and wicks in the circular basin of hemispherical solar still in order to increase the vaporization surface area for better heat transfer of saline water.

Optimization of the hemispherical solar distiller performance assisted by high thermal conductivity metal trays incorporated with reflective mirrors.

The present comprehensive study aims to achieve the highest freshwater productivity of hemispherical solar distillers which are characterized by having a large condensing and receiving surface area. This was done by incorporating two effective modifications to the design of the hemispherical solar distiller, namely the use of metal trays with high thermal conductivity and reflective mirrors. In the present experimental work, three different high thermal conductivity metal trays (steel, zinc, and copper) incorporated with the reflective mirrors were tested under the same climate conditions, in order to determine the optimum selection of metal trays that are incorporated with the reflective mirrors that achieve the highest performance of the hemispherical distillers.

Performance improvements of hemispherical solar still using internal aluminum foil sheet as reflector: energy and exergy analysis.

Various scientists are looking for effective and easy solutions for the augmentation of yield from the hemispherical solar still (HSS). In this study, aluminum foil sheet was used to reflect the intensity, hence augmenting the evaporation rate and daily yield. Experimentations were conducted on two SS: the first SS is HSS; the second SS is HSS with reflective aluminum foil sheet walls (HSS-RAFW).

Combined Blood Indexes of Systemic Inflammation as a Mirror to Admission to Intensive Care Unit in COVID-19 Patients: A Multicentric Study.

Background: The Coronavirus 2019 is a pandemic that has spread worldwide, threatening human health. The main cause of death in patients with COVID-19 is a systemic pro-inflammatory mechanism that quickly progresses to acute respiratory distress syndrome. Hematological ratios as affordable indicators of inflammatory response were studied in COVID-19 patients.

Impact of water depth on thermal efficiency, exergy efficiency, and exergy losses of finned acrylic solar still: an experimental study.

This paper presents a complete exergy analysis and exergy destruction of a finned acrylic solar still (SS) at 1, 2, and 3 cm salt water depth (W). The coefficients of heat transfer of salt water-glass have been computed for evaporative, convective, and radiant heat transfer. Also, thermal efficiency, exergy loss of basin, saltwater, and glass was determined.

Enhancing the hemispherical solar distiller performance using internal reflectors and El Oued sand grains as energy storage mediums.

This paper presents a comprehensive experimental study of the some effective modifications which aim to improve the cumulative productivity of solar distillers, in order to reach the best modification that achieves the highest cumulative productivity of hemispherical distillates. The experimentations were carried on the hemispherical distillers which are characterized by a large area of receiving and condensation. To obtain the best modification that achieves the highest cumulative productivity, the present comprehensive studies were conducted on two experimental scenarios.

A comparative study of hemispherical solar stills with various modifications to obtain modified and inexpensive still models.

The present study aims to obtain the best modification of the hemispherical solar distillers that achieves the highest productivity with the lower inexpensive. To achieve this goal, this paper dealt with conducting a comparative study, operating performance analysis and an economic study of two different modifications, and comparing them with the reference distiller in order to obtain the best adjustments that achieve the highest productivity at the lowest cost. In the first modification, CuO nanoparticles with three different concentrations (0.