Pretherapeutic PSMA PET-Derived Semiquantitative Parameters as Predictors of PSA Response in Patients with mCRPC Receiving [ Lu]Lu-PSMA-617 Radioligand Therapy.

 [ Lu]Lu-prostate-specific membrane antigen (PSMA)-617 radioligand therapy (RLT) shows promise for metastatic castration-resistant prostate cancer (mCRPC) patients with positive PSMA positron emission tomography (PET) imaging. Identifying high-risk patients is crucial. We evaluated pretherapeutic PSMA PET-derived parameters to predict prostate-specific antigen (PSA) response in patients undergoing [ Lu]Lu-PSMA-617 RLT.

Diagnostic Reference Levels in PET Imaging at Chulabhorn Hospital, Thailand.

Diagnostic reference levels (DRLs) are an important tool for controlling radiation exposure and ensuring safety in medical applications. In Thailand, DRL data have been gathered and established for nuclear medicine diagnostics since 2021. However, there is a lack of information on PET imaging examinations.

Head-to-head comparison of F-FDG and F-FES PET/CT for initial staging of ER-positive breast cancer patients.

Purpose: To compare the diagnostic performance of F-fluorodeoxyglucose (F-FDG) and F-fluoroestradiol (F-FES) positron emission tomography/computed tomography (PET/CT) for initial staging of estrogen receptor (ER) positive breast cancer.

Methods: Twenty-eight patients with ER-positive breast cancer underwent F-FDG and F-FES PET/CT for initial staging. Diagnostic performance and concordance rates were analyzed for both radiotracers.

Osteoporosis Prediction Using Machine-Learned Optical Bone Densitometry Data.

Optical bone densitometry (OBD) has been developed for the early detection of osteoporosis. In recent years, machine learning (ML) techniques have been actively implemented for the areas of medical diagnosis and screening with the goal of improving diagnostic accuracy. The purpose of this study was to verify the feasibility of using the combination of OBD and ML techniques as a screening tool for osteoporosis.

Assessing the variability and correlation between SUV and ADC parameters of head and neck cancers derived from simultaneous PET/MRI: A single-center study.

Objective: Intratumoral heterogeneity is associated with poor outcomes in head and neck cancer (HNC) patients owing to chemoradiotherapy resistance. [ F]-FDG positron emission tomography (PET) / Magnetic Resonance Imaging (MRI) provides spatial information about tumor mass, allowing intratumor heterogeneity assessment through histogram analysis. However, variability in quantitative PET/MRI parameter measurements could influence their reliability in assessing patient prognosis.

Comparison of performance between an -FDG PET normal brain template and a commercial template using the software.

Purpose: The aim of this study was to create and validate a normal brain template of -fluorodeoxyglucose ( ) uptake using the MIMneuro software to improve clinical practice.

Approach: One hundred and nine volunteers underwent an positron emission tomography/computed tomography scan. Sixty-three participants with normal Alzheimer's disease (AD) biomarkers were used to create a template.

Comparisons of Quantitative Parameters of Ga-68-Labelled Fibroblast Activating Protein Inhibitor (FAPI) PET/CT and [F]F-FDG PET/CT in Patients with Liver Malignancies.

Purpose: To compare quantitative parameters and tumour detection rates of [ Ga]Ga-FAPI PET/CT with those of dedicated liver PET/MRI and F-FDG PET in patients with liver malignancies.

Procedures: Twenty-seven patients (29 imaging studies) with diagnosed or suspected liver malignancies who underwent [ Ga]Ga-FAPI-46 PET/CT, liver PET/MRI, and [F]FDG PET/CT between September 2020 and June 2021 were retrospectively analysed. MRI findings were used as the reference standard for diagnosis.

Abnormality Pattern of F-18 FDG PET Whole Body with Functional MRI Brain in Post-Acute COVID-19.

Purpose: The study aimed to investigate imaging abnormalities associated with post-acute COVID-19 using F-18 FDG PET/CT and PET/ rsfMRI brain.

Methods: We retrospectively recruited 13 patients with post-acute COVID-19. The post-acute COVID-19 symptoms and neuropsychiatric tests were performed before F-18 FDG PET/CT whole body with PET/rsfMRI brain.

Alterations in 18F-FDG PET/MRI and 15O-Water PET Brain Findings in Patients With Neurological Symptoms After COVID-19 Vaccination: A Pilot Study.

Purpose: This study aimed to investigate functional abnormalities in the brain of patients with neurological adverse effects following COVID-19 (coronavirus disease 2019) vaccination using 18F-FDG PET/MRI and 15O-water PET.

Methods: Eight patients (1 man and 7 women, aged 26-47 years [median age, 36.5 years]) who experienced neurological symptoms after the first COVID-19 vaccination underwent CT, MRI, 18F-FDG PET/MRI, and 15O-water PET of the brain.

Head-to-Head Comparison of Ga-FAPI-46 and F-FDG PET/CT for Evaluation of Head and Neck Squamous Cell Carcinoma: A Single-Center Exploratory Study.

Ga-conjugated fibroblast activation protein inhibitor (Ga-FAPI) has become an attractive agent for PET. This study aimed to compare Ga-FAPI-46 PET/CT with F-FDG PET/CT for detecting primary cancer and metastatic lesions in patients with head and neck squamous cell carcinoma (HNSCC). Twelve patients and 28 patients with HNSCC underwent Ga-FAPI-46 and F-FDG PET/CT for initial staging and recurrence detection, respectively.

Alterations of regional cerebral glucose metabolism usingF-fluorodeoxyglucose positron-emission tomography/computed tomography and electroencephalography analysis during mindfulness breathing in Anapanasati meditation: A preliminary analysis.

Anapanasati is a core meditation of a breath-centered practice in the Buddhist Theravada tradition, which may have some neurological mechanism effects on the brain. To gain insight into the neurological mechanisms involved in Anapanasati meditation, we measured the alterations of regional cerebral glucose metabolism during Anapanasati meditation using positron-emission tomography/computed tomography (PET/CT) and electroencephalography (EEG) analysis. This prospective study was conducted in six right-handed volunteer participants (two men, four women; aged: 32-67 years) who underwentF-fluorodeoxyglucose (F-FDG) PET/CT scans to compare the alterations of regional cerebral glucose metabolism during normal consciousness and Anapanasati meditation states.

The Evaluation of Tau Deposition with [F]PI-2620 by Using a Semiquantitative Method in Cognitively Normal Subjects and Patients with Mild Cognitive Impairment and Alzheimer's Disease.

Background: Some studies have reported the effectiveness of [F]PI-2620 as an effective tau-binding radiotracer; however, few reports have applied semiquantitative analysis to the tracer. Therefore, this study's aim was to perform a semiquantitative analysis of [F]PI-2620 in individuals with normal cognition and patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).

Methods: Twenty-six cognitively normal (CN) subjects, 7 patients with AD, and 36 patients with MCI were enrolled.

C-Pittsburgh compound B and F-THK 5351 positron emission tomography brain imaging in cognitively normal individuals.

Abnormal beta-amyloid plaques and tau protein accumulation are the core pathologic features of Alzheimer's disease. However, the accumulation of these proteins is also common in cognitively normal elderly people. Therefore, this study is aimed to evaluate the amyloid and tau accumulation in the cognitively normal population.

Analysis of amyloid and tau deposition in Alzheimer's disease using C-Pittsburgh compound B and F-THK 5351 positron emission tomography imaging.

This study aims to determine the deposition of C-Pittsburgh compound B (C-PiB) and F-THK 5351 using a normal database of the optimal cut-off-points for standardized uptake value ratios (SUVRs) in Alzheimer's disease (AD) patients. Sixteen AD patients and 24 cognitively normal individuals were enrolled in this study. The optimal cutoff points for the SUVR from the normal database were used for quantitative analysis.

Clinical impact of quantitative [O] HO PET/CT myocardial perfusion imaging on decision-making regarding invasive management of coronary artery disease.

Background: This study was performed to determine the impact of oxygen-15-labeled water ([O] HO) positron emission tomography/computed tomography (PET/CT) myocardial perfusion imaging (MPI) on referral for invasive coronary angiography (ICA) and revascularization.

Methods: This study involved 57 patients who underwent [O] HO PET/CT MPI for evaluation of coronary artery disease (CAD). Data of referral for ICA and revascularization, clinical symptoms, and cardiac events within 6 months after MPI were assessed.

F-THK 5351 and C-PiB PET of the Thai normal brain template.

Objectives: The aim of the study was to create a local normal database brain template of Thai individuals for C-Pittsburgh compound B (C-PiB) and F-THK 5351 depositions using statistical parametric mapping (SPM) software, and to validate and optimize the established specific brain template for use in clinical practice with a highly reliability and reproducibility.

Methods: This prospective study was conducted in 24 healthy right-handed volunteers (13 men, 11 women; aged: 42-79 years) who underwent F-THK 5351 and C-PiB PET/CT scans. SPM was used for the F-THK 5351 and C-PiB PET/CT image analysis.

Evaluation of Imaging Windows for Tau PET Imaging Using F-PI2620 in Cognitively Normal Individuals, Mild Cognitive Impairment, and Alzheimer's Disease Patients.

Background: The study aimed to evaluate the appropriate uptake-timing in cognitively normal individuals, mild cognitive impairment (MCI), and Alzheimer's disease (AD) patients, using F-PI 2620 dynamic PET acquisition.

Methods: Thirty-four MCI patients, 6 AD patients, and 24 cognitively normal individuals were enrolled in this study. A dynamic F-PI 2620 PET study was conducted at 30-75 minutes post-injection in these groups.