Publications by authors named "Attaas T Alvi"
Lack of Offspring Nrf2 Does Not Exacerbate the Detrimental Metabolic Outcomes Caused by PCB126 Exposure.
Front Endocrinol (Lausanne)
February 2022
Article Synopsis
- Human exposure to toxicants like PCBs can increase health risks, particularly during pregnancy and nursing, affecting offspring outcomes.
- Nrf2 plays a crucial role in regulating antioxidant responses and detoxifying harmful substances like PCB126; the study aimed to see how the absence of Nrf2 affects health in PCB-exposed offspring.
- Results showed that Nrf2 heterozygous offspring had lower body weight and lean mass, while Nrf2 knockout offspring had higher fat mass after PCB exposure, and both groups displayed significant glucose metabolism impairments.