Publications by authors named "Atta Ul Mustafa"
Cell Mol Life Sci
April 2024
Article Synopsis
- Diabetic hyperglycemia disrupts arterial smooth muscle function, causing complications due to enhanced vasoconstriction and altered Ca1.2 calcium channel activity.
- In diabetic rat models, it was found that specific splicing changes in the Ca1.2 channel occur, which increase its function and promote vasoconstriction.
- The study highlights that advanced glycation end-products (AGEs), rather than glucose, regulate these changes by affecting the splicing factor Rbfox1, offering a potential target for treating complications in diabetic patients.
Clin Sci (Lond)
June 2022
Article Synopsis
- Calcium influx through CaV1.2 channels is essential for controlling vascular smooth muscle contraction, which helps maintain blood pressure and myogenic tone.
- Alternative splicing of the CaV1.2 channel can be influenced by the RNA-binding protein Rbfox1, whose role in vascular smooth muscle cells (VSMCs) had not been clearly defined before.
- Rbfox1 is shown to reduce splicing changes in CaV1.2, and its knockdown leads to increased vascular constriction in hypertensive conditions, suggesting it could be a potential target for hypertension therapy.
