Publications by authors named "Atsuya Ichikawa"
Article Synopsis
- Ferroptosis is a form of cell death linked to iron and lipid damage, gaining interest for its potential in cancer treatment and toxicity studies.
- The enzyme GPx4, which contains selenium, is a key regulator of ferroptosis, but it's difficult to study accurately due to various factors in lab settings.
- The study reveals that selenium levels in fetal bovine serum (FBS) affect the expression of selenium proteins like GPx4, impacting cell resistance to ferroptosis, emphasizing the need for standardized selenium content in experiments.
Selenoprotein P (SeP, encoded by the SELENOP gene) is a plasma protein that contains selenium in the form of selenocysteine residues (Sec, a cysteine analog containing selenium instead of sulfur). SeP functions for the transport of selenium to specific tissues in a receptor-dependent manner. Apolipoprotein E receptor 2 (ApoER2) has been identified as a SeP receptor.
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