Evaluation of the Effect of Disintegrant Distribution on the Dissolution Behavior of Pharmaceutical Tablets Using Raman Chemical Imaging.

In pharmaceutics, substandard drug manufacturing can sometimes occur. Usually, end-product release tests are conducted to detect defective products, but in many cases, they are not able to identify the root causes of quality defects. In recent years, chemical imaging techniques have been widely used to study quality defects by visualizing the distribution of components in solid dosage forms.