Relationship between severity of renal impairment and 2-year outcomes after sirolimus-eluting stent implantation.

Background: The presence of chronic kidney disease (CKD) is associated with an increased risk of restenosis and major adverse cardiac events (MACEs) after coronary interventions, especially in patients on hemodialysis (HD). The aim of this study was to assess the impact of varying degrees of renal impairment on angiographic and 2-year clinical outcomes after treatment with sirolimus-eluting stents (SESs).

Methods: A total of 675 lesions of 593 patients treated with SES were analyzed.

Molecular characterization the YABBY gene family in Oryza sativa and expression analysis of OsYABBY1.

Members of the YABBY gene family have a general role that promotes abaxial cell fate in a model eudicot, Arabidopsis thaliana. To understand the function of YABBY genes in monocots, we have isolated all YABBY genes in Oryza sativa (rice), and revealed the spatial and temporal expression pattern of one of these genes, OsYABBY1. In rice, eight YABBY genes constitute a small gene family and are classified into four groups according to sequence similarity, exon-intron structure, and organ-specific expression patterns.

Accumulation of Hsp70/Hsc70 molecular chaperone regulator BAG-1 on COPI-coated structures in gastric epithelial cells.

The multifunctional protein BAG-1 binds to molecular chaperones Hsc70/Hsp70 and regulates their activity. While a role for BAG-1 in regulating Hsc70 chaperone activity is firmly established in vitro, physiological roles of this regulation remain obscure. Here we show that BAG-1 is highly expressed in gastrointestinal epithelial cells and accumulates at the Golgi apparatus, probably through interaction with COPI coated structure.