Publications by authors named "Atsushi Takahata"
[Acquired thrombotic thrombocytopenic purpura with rituximab-induced serum sickness].
Rinsho Ketsueki
November 2024
The patient was a 38-year-old man who was admitted to our hospital with fever, vomiting and unclear speech. Blood tests showed hemolytic anemia, thrombocytopenia, and elevated creatinine, and a Coombs test was negative. ADAMTS13 activity was <1% and ADAMTS13 inhibitor was 0.
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- Primary leptomeningeal malignant lymphoma (PLML) is a rare form of primary central nervous system lymphoma (PCNSL) with no established treatment due to its uniqueness.* -
- A case study of a 46-year-old male with PLML showed complete remission after treatment with a combination of chemotherapy (R-MPV and intrathecal agents) and autologous stem-cell transplantation (ASCT) using a thiotepa regimen.* -
- A literature review indicated that ASCT has been successfully used in three reported cases of PLML, suggesting it may be an effective consolidation therapy, but more research is necessary to develop standardized treatment guidelines.*
Article Synopsis
- * In a reported case, plasma cells appeared in a patient's blood during treatment, but they were deemed reactive and disappeared on their own, leading to successful hematopoietic recovery.
- * This case is significant as it is the first documented instance of reactive plasmacytosis occurring during immunosuppressive therapy for aplastic anemia, suggesting that it could indicate a positive treatment response.
Although alectinib is effective for relapsed or refractory ALK-positive anaplastic large cell lymphoma (ALCL) and has a favorable safety profile, its role as a bridging therapy for allogeneic hematopoietic stem cell transplantation (allo-HSCT) and the role of allo-HSCT itself in this setting are unknown. A 35-year-old man with ALK-positive ALCL experienced relapse after first-line therapy with CHOP. Brentuximab vedotin led to partial response and high-dose chemotherapy combined with autologous HSCT was performed.
View Article and Find Full Text PDFLight chain proximal tubulopathy (LCPT) is a rare type of monoclonal gammopathy of renal significance. Clinicians should consider LCPT in the differential diagnosis of patients with renal or proximal tubular dysfunction with monoclonal gammopathy. They should confirm diagnosis by renal biopsy and initiate chemotherapy before disease progression.
View Article and Find Full Text PDFParoxysmal nocturnal hemoglobinuria (PNH) is characterized by hemolysis, thrombosis, and bone marrow failure. Infection, pregnancy, and surgical operation have the potential to evoke severe episodes of hemolysis and thrombosis. Therefore, the use of an antibody agent against complement component 5 (C5), eculizumab, one day before the operation is recommended.
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