Publications by authors named "Atsushi Seichi"

Article Synopsis
  • Ossification of the posterior longitudinal ligament of the spine (OPLL) is a disease that can cause serious neurological issues, and its causes are not fully understood, particularly in relation to type 2 diabetes and high body mass index (BMI).
  • A comprehensive meta-analysis involving 22,016 Japanese individuals identified 14 significant genetic markers linked to OPLL, with 8 being newly discovered, and further analyses pointed to specific genes associated with the disease.
  • The research revealed that increased BMI and high bone mineral density could have a causal relationship with OPLL, and different subtypes of the disease were identified, particularly highlighting a strong correlation between BMI and thoracic OPLL.
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Background: The number of elderly sports participants is increasing, and the possibility of return to sport (RTS) has become an important part of surgical decision making in this population.

Purpose: To investigate RTS after elective spinal surgery in elderly patients.

Study Design: Case series; Level of evidence, 4.

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Importance: The optimal management for acute traumatic cervical spinal cord injury (SCI) is unknown.

Objective: To determine whether early surgical decompression results in better motor recovery than delayed surgical treatment in patients with acute traumatic incomplete cervical SCI associated with preexisting canal stenosis but without bone injury.

Design, Setting, And Participants: This multicenter randomized clinical trial was conducted in 43 tertiary referral centers in Japan from December 2011 through November 2019.

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Introduction: Morel-Lavallée lesion (MLL) is a posttraumatic closed degloving soft tissue injury, in which the subcutaneous tissues are separated from the underlying fascia. Surgical treatment is recommended if conservative management fails. The conventional surgical treatment for the lesion is surgical drainage and debridement.

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Article Synopsis
  • The study aimed to examine the connection between body mass index (BMI) changes, lifestyle, and reproductive factors in relation to knee pain among middle-aged women.
  • Conducted as part of the Japan Nurses' Health Study, it involved 7,434 women over 10 years, analyzing self-reported knee pain alongside their BMI trajectories.
  • Results indicated that women who remained overweight or gained weight had a significantly higher risk of knee pain, while those who lost weight had a lower risk, highlighting the importance of maintaining a normal BMI for knee health.
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Study Design: Cross-sectional observational study (consecutive case series).

Objectives: The aim of this study was to define a criterion for achieving successful decompression of lumbar spinal stenosis (LSS) using intraoperative ultrasonography (IOUS) and to investigate the pathogenesis of redundant nerve roots (RNRs) based on the ultrasonographic findings.

Methods: A total of 100 LSS patients (71 males, 29 females, mean age, 71 ± 8 years) with RNRs were enrolled as subjects in this study.

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Osteoarthritis (OA) of the knee is one of the main causes of mobility decline in the elderly. Non-surgical treatments such as administration of supplements to strengthen the joint cartilage matrix have become popular not only for pain relief but also for joint preservation. Glucosamine has been used in many countries based on the increasing evidence of its effectiveness for OA.

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Introduction: Pulmonary embolism (PE) is a risk of mortality following spine surgery. Many studies have demonstrated that deep venous thrombosis (DVT) may affect and actually advance to PE, but few studies have shown how venous thromboembolism (VTE), including PE and DVT, affect blood markers after spine surgery. In this study, we examined changes in blood markers with PE or DVT after low-risk spine surgery, namely cervical laminoplasty or lumbar laminectomy.

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Background: Fall-induced injuries represent a major public health concern for older individuals. The relationship between risk of falling and the severity of locomotive syndrome (LS) remains largely unknown.

Methods: We conducted a retrospective analysis of patients who had undergone surgery from January 2012 to December 2013 and completed at least 1 year of follow-up at 12 participating institutes.

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Background: Ageing is associated with a decline of motor function and ability to perform daily activities. Locomotive disorders are one of the major disorders resulting in adverse health condition in elderly people. Concept of Locomotive syndrome (LoS) was proposed to tackle the problems and prolong healthy life expectancy of people with locomotive disorders.

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This meta-analysis was performed to determine the effect of balneotherapy on relieving pain and stiffness and improving physical function, compared to controls, among patients with knee osteoarthritis. We searched electronic databases for eligible studies published from 2004 to December 31, 2016, with language restrictions of English or Japanese. We screened publications in Medline, Embase, Cochrane library, and the Japan Medical Abstracts Society Database using two approaches, MeSH terms and free words.

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Purpose: Locomotive disorders due to musculoskeletal involvement are one of the main causes requiring long-term care services in aging Japan. "Locomotive syndrome (LoS)" is a concept referring to the condition under which people require assistance from others or at risk in future. The object of this study is to examine the relationship between self-reported measure and physician-judged degrees on ADL disability in elder people with locomotive disorders.

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Study Design: Retrospective multi-center study.

Objective: This study was conducted to clarify the incidence and neurological outcomes of fall-related deterioration of subjective symptoms in patients undergoing surgical treatment.

Summary Of Background Data: The evidence that minor trauma, including falls, increases the risk of worsening cervical myelopathy is insufficient.

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Objective: To assess the predictive factors for subjective improvement with nonsurgical treatment in consecutive patients with lumbar spinal stenosis (LSS).

Materials And Methods: Patients with LSS were enrolled from 17 medical centres in Japan. We followed up 274 patients (151 men; mean age, 71 ± 7.

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Background: The authors have developed a screening tool, the 25-Geriatric Locomotive Function Scale (GLFS-25), for the early detection of locomotive syndrome (LS). However, few studies have examined the prevalence of LS in the general population. This study estimated the prevalence of LS in Japan using the GLSF-25 and investigated age specific mean values for this scale.

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Study Design: A prospective study.

Objective: The aim of this study was to elucidate the impact of axial pain following cervical laminoplasty on health-related quality of life (HRQOL).

Summary Of Background Data: Axial neck pain is a frequently encountered complication after laminoplasty.

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We report 2 cases of acute, progressive myelopathy after a fall in elderly patients who had a retroodontoid pseudotumour and extensive ossification of the anterior longitudinal ligament.

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Locomo 25 was developed as a screening tool of locomotive syndrome by Japanese orthopedic surgeon group in 2008. It contains 25 questions in terms of musculoskeletal disorder such as walking disability, difficulty in daily living, or suffering pain on body. Its reliability and validity were already confirmed through multi-center study including 731 Japanese elderly people (over 65 y.

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[Lumbar spondylosis].

Nihon Rinsho

October 2014

Lumbar spondylosis is a chronic, noninflammatory disease caused by degeneration of lumbar disc and/or facet joints. The etiology of lumbar spondylosis is multifactorial. Patients with lumbar spondylosis complain of a broad variety of symptoms including discomfort in the low back lesion, whereas some of them have radiating leg pain or neurologenic intermittent claudication (lumbar spinal stenosis).

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Object: Despite its potential clinical impact, information regarding progression of thoracic ossification of the posterior longitudinal ligament (OPLL) is scarce. Posterior decompression with stabilization is currently the primary surgical treatment for symptomatic thoracic OPLL; however, it remains unclear whether thoracic OPLL increases in size following spinal stabilization. It is also unknown whether patients' clinical symptoms worsen as OPLL size increases.

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Study design Prospective cohort study. Objective The purpose of the present study was to identify the predictors of patient satisfaction with outcome after cervical laminoplasty for compressive cervical myelopathy. Methods A cohort of 143 patients with compressive myelopathy who underwent cervical double-door laminoplasty between 2008 and 2011 was studied prospectively.

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Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common spinal disorder among the elderly that causes myelopathy and radiculopathy. To identify genetic factors for OPLL, we performed a genome-wide association study (GWAS) in ∼8,000 individuals followed by a replication study using an additional ∼7,000 individuals. We identified six susceptibility loci for OPLL: 20p12.

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Background: The authors recently developed a screening tool, the 25-question Geriatric Locomotive Function Scale (GLFS-25), for the early detection of locomotive syndrome (LS). However, the nationwide prevalence of LS based on the GLFS-25 remains unknown.

Methods: A nationwide, cross-sectional Internet survey was conducted to estimate sex- and age-specific mean values of the GLFS-25 and the total number of individuals with LS in Japan.

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Objective: To establish the cutoff time for the one-leg standing (OLS) test (with eyes open) to use when screening elderly people for locomotive syndrome.

Methods: Patients visiting orthopedic clinics and healthy volunteers, all ≥65 years old, were recruited. Participants were asked to complete the 25-question Geriatric Locomotive Function Scale (GLFS-25) and then underwent the OLS test.

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Study Design: A retrospective study.

Objective: To investigate the morphology of the cervical spine in patients with athetoid cerebral palsy (CP), and to evaluate its relationship with the breach of cervical pedicle screws.

Summary Of Background Data: Cervical pedicle screws have been increasingly used in surgery for patients with CP, but screw misplacement is not uncommon.

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