Publications by authors named "Atsushi Ninomiya"
Article Synopsis
- Human induced pluripotent stem cells (hiPSCs) lacking HLA class I can potentially evade T cell rejection and be used in universal cell therapies; however, they face rejection from natural killer (NK) cells.
- The study utilized humanized mice to test the tolerance of HLA-edited hiPSC-derived cells after enhancing NK cell development using cord blood stem cells and specific cytokines like IL-15.
- The findings demonstrated that while HLA class I-null hiPSC-derived cells were rejected by NK cells, those expressing HLA-C could evade this rejection, suggesting a pathway for developing off-the-shelf regenerative medicine strategies.
A one-pot synthesis of oxazolidinones was initiated via the allylation of alpha-dicarbonyl compounds, accompanying regio- and diastereo-controlled carbon-carbon bond formation on the side chains of the oxazolidinones.
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