Publications by authors named "Atsushi Kunisaki"
Decellularised nerve transplantation has limited therapeutic efficacy for peripheral nerve injuries. In this study, we tested the hypothesis that nerve regeneration can be promoted by increasing blood circulation to the decellularised nerve through the surrounding blood-flow environment. We transplanted 20 mm decellularised nerves into sciatic nerve defects in Sprague-Dawley rats (female, 12 weeks old).
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- This study explored the use of hydrophilized carbon nanotubes (CNTs) to enhance peripheral nerve regeneration and reduce foreign body reactions in a rat model.
- Three different treatments of CNTs were tested: oxidation with ozone, strong acid treatment, and no treatment, each implanted into rat sciatic nerve defects.
- The results indicated that CNTs treated with strong acid significantly improved nerve recovery and reduced inflammation after 16 weeks, showing better functional and structural outcomes compared to the other groups.
Carbon nanotubes (CNTs) are cylindrical nanostructures and have unique properties, including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn) as a possible substrate promoting peripheral nerve regeneration with these properties. We bridged a 15 mm rat sciatic nerve defect with five different densities of cYarn.
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