Publications by authors named "Atsumi Hosokawa-Tsuji"
In contrast to the glucocorticoid maintenance therapy employed in patients with 21 hydroxylase deficiency (21OHD), the initial therapy remains to be optimized. The Japanese Society for Pediatric Endocrinology recommends a hydrocortisone (HC) dose of 25-100 mg/m, which is higher than that employed in Western countries. Herein, we aimed to retrospectively verify the impact of initial HC treatment during infancy and early childhood.
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- Hematopoietic stem cell transplantation (HSCT) can cure serious blood-related diseases in children, but survivors may face significant long-term health issues, particularly metabolic complications like diabetes and high cholesterol.
- A study analyzed 22 pediatric HSCT survivors, finding that 4 developed diabetes and 9 developed high cholesterol, with all diabetes cases accompanied by insulin resistance.
- Total body irradiation (TBI) was identified as a key risk factor for developing diabetes, especially when performed before age six, and none of the diabetic participants were obese.