Stromal area differences with epithelial-mesenchymal transition gene changes in conjunctival and orbital mucosa-associated lymphoid tissue lymphoma.

Purpose: To examine the molecular biological differences between conjunctival mucosa-associated lymphoid tissue (MALT) lymphoma and orbital MALT lymphoma in ocular adnexa lymphoma.

Methods: Observational case series. A total of 129 consecutive, randomized cases of ocular adnexa MALT lymphoma diagnosed histopathologically between 2008 and 2020.

Growth and maturation of megakaryocytes is regulated by Lnk/Sh2b3 adaptor protein through crosstalk between cytokine- and integrin-mediated signals.

Objective: Various cytokines and growth factors control the differentiation and maturation of megakaryocytes (MKs). However, the mechanism regulating platelet release from MKs is not well understood. Here, we investigated a role of Lnk/Sh2b3, an intracellular adaptor protein, in megakaryopoiesis.

Seasonal changes in urinary prostate-specific antigenic activity in male Japanese macaques (Macaca fuscaa fuscata).

Prostate-specific antigen (PSA) is usually detected in male adult urine and semen according to the Tanner stage development of males from birth to adolescence. To further study the pituitary-testicular axis in males, we determined urinary PSA levels in primates. Urinary PSA was detected with the use of anti-human PSA monoclonal antibody in male adult Japanese macaques (Macaca fuscaa fuscata) of seasonal breeding status.

Urinary prostate-specific antigen is a noninvasive indicator of sexual development in male children.

Testicular androgen induces the synthesis of prostate specific antigen (PSA) in acinar epithelial cells of the prostate. We examined PSA activity in urine from 136 male children from birth up to 17 years of age. We detected PSA at various intervals in early infant urine over a period of 1-4 months.