Induced next-day somnolence in an elderly patient taking suvorexant concomitantly with diltiazem.

Objective: To present the first case of induced next-day somnolence in a patient taking suvorexant concomitantly with diltiazem.

Case Summary: The patient was an 88-year-old female who had suffered from insomnia and anorexia, for which a psychiatric clinic had prescribed 1.5 mg/day aripiprazole and 15 mg/day suvorexant (both once daily at bedtime), which cured her insomnia.

First case report of suspected onset of convulsive seizures due to co-administration of valproic acid and tebipenem.

Objective: A patient presented with convulsive seizures when sodium valproate (VPA) and tebipenem pivoxil (Orapenem) were co-administered accidentally. The seizures were suspected to be caused by a reduced concentration of VPA in the blood.

Case Summary: A 6-year-old boy (weight: 16 kg, at the start of treatment) began sodium valproate (valproate syrup 5%) treatment for epilepsy in February 2012.