Prolyl isomerase Pin1 is required sperm production by promoting mitosis progression of spermatogonial stem cells.

A prolyl isomerase Pin1 deficient (Pin1) male mice had severe testicular atrophy. We investigated the function of Pin1 in spermatogenesis by analyzing the Pin1 mice at reproductive age. Pin1 mice had lessαPLZF positive spermatogonia (undifferentiated spermatogonia) than wild type (WT).