Publications by authors named "Atsuko Goto"
Article Synopsis
- The study investigates multiple system atrophy (MSA) patients with a specific focus on those showing significant pathological changes in the hippocampus, a region of the brain involved in memory.
- Out of 146 autopsied MSA patients, 12 (8.2%) exhibited severe neuronal cytoplasmic inclusions (NCIs) in the hippocampus and associated areas, showing a distinct profile compared to the rest.
- Notable findings include a higher number of affected women, longer disease duration, increased cognitive impairment, and distinctive NCI morphologies, indicating the need for further understanding of MSA variants linked to hippocampal pathology.
Objective: This study was performed to analyze the locomotion outcome of hemiplegic patients with stroke and to explore the factors influencing it.
Methods: A total of 247 patients (mean age 65.6 +/- 10.
The deposition of abnormal levels of tau protein is a major neuropathological feature of progressive supranuclear palsy (PSP), and the presence of tuft-shaped astrocytes is a neuropathological hallmark of PSP. We examined the topographic distribution of tuft-shaped astrocytes in the cerebral hemisphere by Gallyas-Braak silver staining in three Japanese autopsy cases of typical PSP. The distribution of tuft-shaped astrocytes was relatively uniform between cases.
View Article and Find Full Text PDFSeveral investigators have revealed features of multiple system atrophy (MSA) by magnetic resonance imaging (MRI). For use in clinical diagnosis, we determined the exact time when two main features of pontine and putaminal intensity changes appeared. Furthermore, in order to reveal the course from when the disorder first appeared and how it spread, we also investigated the course of MRI findings and differences between clinical subtypes.
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