Publications by authors named "Atsuhito Nakao"
The circadian clock (CC) has biological and clinical implications in gliomas. Most studies focused on CC effects on the tumor microenvironment and the application of chronotherapy. The present study focused on CC gene expression patterns and intracellular oncogenic activities.
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- MOD000001 is a newly discovered compound that acts as a selective inhibitor of the KIT kinase, which plays a key role in mast cell proliferation and survival, making it a potential treatment for allergic diseases.
- The study showed that MOD000001 effectively inhibits KIT signaling in both human and mouse mast cells, reducing their activation in response to IgE and SCF.
- Long-term treatment with MOD000001 resulted in decreased skin mast cell numbers in mice, indicating its potential to alleviate allergic reactions associated with mast cells.
Cha o 3, a cypress pollen allergen, does not activate basophils in Japanese cypress pollinosis.
J Allergy Clin Immunol Glob
February 2024
Article Synopsis
- In Japan, JCy pollinosis (a seasonal allergy) is primarily caused by two major allergens from Japanese cypress pollen: Cha o 1 and Cha o 2, with a new allergen, Cha o 3, recently identified.
- A study with 27 patients examined the allergenic effects of Cha o 3 compared to Cha o 1 and Cha o 2 using basophil activation tests and IgE suppression tests.
- The findings showed that Cha o 3 activated basophils much less than Cha o 1 and Cha o 2, suggesting it is not a significant allergen in JCy pollinosis.
Background: , the gene which encodes organic cation transporter (OCT)-3, has been linked to the prognosis of several types of cancer. However, its role in lung squamous cell carcinoma (LSCC) has not been addressed elsewhere.
Methods: We analyzed gene expression, DNA methylation, and clinicopathological data from The Cancer Genome Atlas - Lung Squamous Cell Carcinoma (TCGA-LUSC) (n=501), a publicly available database exclusively consisting of LSCC patients.
Article Synopsis
- - Bmal1 is a transcription factor important for the circadian clock and has an unclear role in mast cell function, which is crucial in allergic reactions and follows a daily rhythm.
- - The study found that mast cells lacking Bmal1 showed increased IgE-dependent degranulation and higher oxidative stress markers compared to normal mast cells, suggesting a link between Bmal1 and mast cell activity.
- - Overall, the research indicates that Bmal1 regulates anti-oxidative gene expression in mast cells, and its deficiency leads to heightened allergic responses due to increased oxidative stress.
Ethyl caffeate (EC) is a natural phenolic compound that is present in several medicinal plants used to treat inflammatory disorders. However, its anti-inflammatory mechanisms are not fully understood. Here, we report that EC inhibits aryl hydrocarbon receptor (AhR) signaling and that this is associated with its anti-allergic activity.
View Article and Find Full Text PDFThe pathology of asthma is characterized by marked day-night variation, which is likely controlled by circadian clock activity. This study aimed to clarify the association of core circadian clock gene expression with clinical features of asthma. For this purpose, we accessed the National Center for Biotechnology Information database and analyzed transcriptomes of peripheral blood mononuclear cells and clinical characteristics of 134 pediatric/adolescent patients with asthma.
View Article and Find Full Text PDFTime will tell about mast cells: Circadian control of mast cell activation.
Allergol Int
October 2022
Mast cell activation is crucial to the development of allergic disease. New studies have shown that both IgE-dependent and -independent mast cell activation is temporally regulated by the circadian clock, a time-of-day-keeping system that consists of transcriptional-translational feedback loops of several clock genes. For instance, the core clock gene Clock controls the expression of the high-affinity IgE receptor (FcεRI) and interleukin-33 (IL-33) receptor ST2 on mast cells in a time-dependent manner.
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- * 41 women took probiotics while 19 served as a control, with milk samples collected at one, two, and three months postpartum.
- * Significant changes were observed in certain cytokines like IL-1 receptor antagonist, IL-7, and IL-10, suggesting probiotics may influence cytokine levels, but further placebo-controlled studies are needed for conclusive results.
Allergic diseases such as allergic rhinitis, asthma, atopic dermatitis, and food allergy are characterized by epithelial barrier dysfunction and deregulated immune responses. Components of the circadian clock interact with critical elements of epithelial barrier function and immune responses, and regulate the biological processes on a 24-h cycle at steady state. This may represent an anticipatory defense response to day-night fluctuation of attack by noxious stimuli such as pathogens in the environment.
View Article and Find Full Text PDFNovel coronavirus (SARS-Coronavirus-2:SARS-CoV-2) which emerged in Wuhan, China, has spread to multiple countries rapidly. We report the first case of meningitis associated with SARS-CoV-2 who was brought in by ambulance due to a convulsion accompanied by unconsciousness. He had never been to any foreign countries.
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- Secretory immunoglobulin A (SIgA) is a crucial antibody that helps maintain a barrier in the mucosal surfaces and interacts with friendly gut bacteria.
- Research shows that butyrate, a substance produced by these bacteria, triggers a response that leads to the production of SIgA without needing T-cells.
- This process enhances the gut's ability to prevent bacteria from spreading during inflammation, suggesting that butyrate plays a vital role in keeping the gut immune system balanced.
The cell-autonomous circadian clock regulates IgE- and IL-33-mediated mast cell activation, both of which are key events in the development of allergic diseases. Accordingly, clock modifiers could be used to treat allergic diseases, as well as many other circadian-related diseases, such as sleep and metabolic disorders. The nuclear receptors REV-ERB-α and -β (REV-ERBs) are crucial components of the circadian clockwork.
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- Interleukin-33 (IL-33) and its receptor ST2 are key players in activating mast cells, which are implicated in allergic diseases.
- Resveratrol, a natural compound, has been found to inhibit mast cell activation triggered by IL-33 and also reduces the production of inflammation-related cytokines like IL-6 and TNF-α.
- The mechanism of action indicates that resveratrol targets the MK2/3-PI3K/Akt pathway, providing a potential therapeutic approach for treating various allergic conditions.
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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- Venomous snakebites cause serious local tissue damage and can lead to severe complications like hypovolemic shock, but the exact mechanisms behind these effects are not fully understood.
- This study discovers that the venom protein rhodocytin from the Malayan viper activates blood platelets through the C-type lectin-like receptor 2 (CLEC-2), which then triggers mast cells to release histamine.
- The findings highlight a new mechanism for how snake venom can increase blood vessel permeability via interactions between activated platelets and mast cells, emphasizing the role of ATP and the P2X7 receptor in this process.
Article Synopsis
- A study investigated the safety and effects of probiotic supplementation in lactating mothers with allergies, using specific probiotic strains over a two-month period postpartum.* -
- Results showed no adverse effects from the probiotics, with a high adherence rate of 91.5%, but changes in immunoglobulin A (IgA) and transforming growth factor-β (TGF-β) levels varied and did not show a clear beneficial impact.* -
- This research highlights the potential of probiotics in maternal diet for infant allergy prevention, but also points out the inconsistency and controversy surrounding their nutritional and safety benefits.*