[Cimetidine inhibits the adhesion of cancer cells with sialyl Lewis epitope onto the vascular endothelium].

The attachment of circulating cancer cells to vascular endothelium is considered an important initial step in hematogenous metastasis. We believe that hematogenous metastasis can be inhibited by blocking the adhesion of cancer cells to vascular endothelium. We demonstrated that cimetidine suppressed the expression of E-selectin on the surface of HUVECs, which was a ligand to the sialyl Lewis (sLe) epitope.

[Ultrastructural changes of collagen fibrils in mouse dermal connective tissue after moxibustion treatment].

Morphological changes in mouse back skin, especially dermal connective tissue, were observed after moxibustion treatment. Various amounts of direct moxibustion and indirect moxibustion (column) were performed and the exact skin area was processed for light and electron microscopy. Just after treatment, epidermal cell layer was degenerated and increased amounts of mast cells were observed.