Publications by authors named "Atossa C Ghorashi"
Article Synopsis
- Cholera toxin (CT) causes cholera by binding to intestinal cells, and different types of fucosylated glycoconjugates are involved in this process.
- Knocking out the B3GNT5 gene reduces CT binding in Colo205 cells but makes them more sensitive to CT intoxication, while increasing B3GNT5 levels can protect against CT.
- Conversely, knocking out B3GALT5 increases production of certain glycoproteins that enhance CT binding and intoxication, highlighting the role of fucosylated glycoproteins as important receptors for CT.
Cholera toxin (CT) is the etiological agent of cholera. Here we report that multiple classes of fucosylated glycoconjugates function in CT binding and intoxication of intestinal epithelial cells. In Colo205 cells, knockout of B3GNT5, the enzyme required for synthesis of lacto- and neolacto-series glycosphingolipids (GSLs), reduces CT binding but sensitizes cells to intoxication.
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