Clinical course of ulcerative colitis in patients with and without primary sclerosing cholangitis.

Background And Aim: We noticed in our practice that patients with ulcerative colitis (UC) who have developed primary sclerosing cholangitis (PSC) experience a milder course of colonic disease. Our objective in this study was to define whether or not there is any difference between UC activity and its course in patients with and without PSC.

Methods: Nineteen patients with UC and PSC (eight male, mean age 25 years) were enrolled.