Publications by authors named "Atikam Qurban"
Cellular Cholesterol Loss Impairs Synaptic Vesicle Mobility via the CAMK2/Synapsin-1 Signaling Pathway.
Front Biosci (Landmark Ed)
January 2025
Background: Neuronal cholesterol deficiency may contribute to the synaptopathy observed in Alzheimer's disease (AD). However, the underlying mechanisms remain poorly understood. Intact synaptic vesicle (SV) mobility is crucial for normal synaptic function, whereas disrupted SV mobility can trigger the synaptopathy associated with AD.
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- Studies show that a protein called DHCR24 is important for making cholesterol in the brain, especially for people with Alzheimer's Disease (AD).
- When DHCR24 isn't working well, it leads to less cholesterol, which is links to brain problems like the buildup of certain harmful substances.
- There is growing evidence that losing cholesterol in the brain could be connected to the causes of Alzheimer's Disease.