Publications by authors named "Atika Zouine"
The involvement of γδ TCR-bearing lymphocytes in immunological memory has gained increasing interest due to their functional duality between adaptive and innate immunity. γδ T effector memory (TEM) and central memory (TCM) subsets have been identified, but their respective roles in memory responses are poorly understood. In the present study, we used subsequent mouse cytomegalovirus (MCMV) infections of αβ T cell deficient mice in order to analyze the memory potential of γδ T cells.
View Article and Find Full Text PDFBackground: Thrombo-inflammation and neutrophil extracellular traps (NETs) are exacerbated in severe cases of COVID-19, potentially contributing to disease exacerbation. However, the mechanisms underpinning this dysregulation remain elusive. We hypothesised that lower DNase activity may be associated with higher NETosis and clinical worsening in patients with COVID-19.
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- Hepatocellular carcinoma (HCC) is linked to inflammation and can arise from liver diseases, leading to an increase in immunosuppressive myeloid cells, which complicates immunotherapy effectiveness.
- A detailed study of innate immune cells in HCC patients revealed an influx of inflammatory and myeloid cells, particularly a distinct type of THBS1 regulatory myeloid cells, which are associated with poor patient outcomes.
- THBS1 M cells, marked by specific gene expressions and characterized by their role in promoting tumor growth and immunosuppression, suggest that targeting these myeloid subsets could improve HCC immunotherapy strategies.
Article Synopsis
- * The study found increased levels of follicular helper T cells (Tfh) in untreated CLL patients, which were linked to more severe disease, as indicated by the Binet staging system.
- * Tfh cells in CLL patients showed an activated Th1-like phenotype and were found to promote B-CLL cell survival and proliferation through IL-21, while also showing an association with immune dysfunction in CLL, as suggested by the relationship with serum IgA and IgG levels.
Background: The reported association of mTOR-inhibitor (mTORi) treatment with a lower incidence of cytomegalovirus (CMV) infection in kidney transplant recipients (KTR) who are CMV seropositive (R+) remains unexplained.
Methods: The incidence of CMV infection and T-cell profile was compared between KTRs treated with mTORis and mycophenolic acid (MPA), and mTORi effects on T-cell phenotype and functions were analyzed.
Results: In KTRs who were R+ and treated with MPA, both and T cells displayed a more dysfunctional phenotype (PD-1+, CD85j+) at day 0 of transplantation in the 16 KTRs with severe CMV infection, as compared with the 17 KTRs without or with spontaneously resolving CMV infection.
Article Synopsis
- Cytomegalovirus (CMV) is a significant cause of complications and mortality post-transplantation, and specific T cell responses are crucial for recovery.
- The study focuses on a particular subgroup of T cells, Vγ9negVδ2pos, which are distinct from other T cell types and play a role in the immune response to CMV.
- These Vγ9negVδ2pos T cells show potential for use as an immune marker to gauge the severity of CMV disease in kidney transplant patients.
Human NK lymphocytes are involved in antitumor immunity. The therapeutic potential of this population against cancers has stimulated their study and led to the discovery of several NK cell subsets, each of which is endowed with different immunoregulatory functions. We have previously reported that NK cell functions are profoundly altered in advanced breast cancer patients.
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