Design, Synthesis and Anticancer Evaluation of New Substituted Thiophene-Quinoline Derivatives.

A series of new isoxazolyl, triazolyl and phenyl based 3-thiophen-2-yl-quinoline derivatives were synthesized adopting click chemistry approach. In addition, the synthesis of new useful synthon, (2-chloroquinolin-3-yl) (thiophen-2-yl) methanol, is reported. The obtained compounds were characterized by spectral data analysis and evaluated for their anticancer activity.

Synthesis, molecular modeling and anticancer activity of new coumarin containing compounds.

A series of new coumarin containing compounds were synthesized from 4-bromomethylcoumarin derivatives and different heteroaromatic systems methylene thiolinker. Twenty-four compounds were screened biologically against two human tumor cell lines, breast carcinoma MCF-7 and hepatocellular carcinoma HePG-2, at the national cancer institute, Cairo, Egypt using 5-fluorouracil as standard drug. Compounds hh and showed strong activity against both MCF-7 and HepG-2 cell lines with being compound is the most active with IC values of 5.