Publications by authors named "Atif Adnan"
Article Synopsis
- X-chromosomal short tandem repeats (X-STRs) are vital for forensic investigations and understanding population genetics, yet there's scarce data on their variation in Pakistani ethnic groups, specifically Kashmiris and Punjabis.
- This research examined 12 X-STRs from 125 families (75 Kashmiri and 50 Punjabi) in Pakistan, showcasing 222 total alleles, with allele frequencies varying widely, and highlighting specific loci variance in polymorphism.
- Findings indicated strong discrimination power for kinship analysis and revealed distinct genetic structures between Kashmiri and Punjabi populations, emphasizing their unique genetic backgrounds and differences from East Asian groups.
Article Synopsis
- The Hui people are the second-largest ethnic minority in China, and this study focuses on their paternal genetic makeup in Liaoning province, an area previously not studied.
- Researchers analyzed 282 unrelated Hui males using Y-chromosome markers, revealing high haplotypic diversity and identifying 46 distinct haplogroups.
- Analyses showed the Hui population can be grouped into three distinct groups and exhibited genetic similarities to the Han population, which can improve the understanding of their genetic structure for forensic purposes.
Article Synopsis
- Mixed semen stains found in sexual assault cases can be challenging to analyze for identifying the perpetrator, as they often come from multiple individuals.
- A new method called magnetic bead-based separation is used to isolate sperm cells by utilizing magnetic microspheres and antibodies targeting specific blood groups.
- The process involves amplifying DNA from the isolated sperm cells with PCR and analyzing it through capillary electrophoresis to identify unique genetic markers (STR loci) for different individuals.
Article Synopsis
- Differentiating between monozygotic (MZ) twins is challenging due to their identical genetic makeup, making traditional STR genotyping ineffective.
- Heteroplasmy, the presence of multiple mtDNA types within a single cell, is common in humans and can vary during transmission and in somatic tissues.
- This study employed advanced massively parallel sequencing (MPS) and a specific probe hybridization technique, allowing clear differentiation of ten pairs of MZ twins by analyzing mtDNA at very low heteroplasmy thresholds.
Article Synopsis
- The study examined 17 Y-chromosomal STRs in 493 unrelated individuals from four Pakistani ethnic groups: Baloch, Pathan, Punjabi, and Sindhi, to analyze forensic parameters and genetic structure.
- Eighty-two distinct haplotypes were identified, with haplotype diversity values ranging from 0.9906 in Baloch to 0.9957 in Pathans, indicating significant genetic variation within these groups.
- The results suggest that these populations share genetic similarities with Central Asian and Northern Indian regions, and the low gene diversity may be influenced by endogamy practices.
Article Synopsis
- The text discusses a correction made to the findings presented in the article with the DOI: 10.3389/fgene.2021.760760.
- The correction addresses specific errors or inaccuracies that were identified after the original publication.
- This ensures that the scientific community has access to accurate information and maintains the integrity of the reported research.
Article Synopsis
- * This study analyzed mutation rates in 9379 pairs of men across 30 RM Y-STRs and found significant differences in mutation rates compared to standard Y-STRs, revealing higher differentiation rates among more distantly related individuals.
- * The results indicate that RM Y-STRs can accurately predict the degree of patrilineal relatedness, with potential to greatly enhance forensic Y-chromosome analysis compared to traditional methods.
Article Synopsis
- * Rapidly mutating Y-STRs (RM Y-STRs) have higher mutation rates and can better differentiate male lineages, especially in endogamous groups, than traditional Y-STRs.
- * This study analyzed 861 male pairs from Punjabi endogamous pedigrees, observing varying mutation frequencies, with overall differentiation rates averaging 59.46%, and updated mutation rates for RM Y-STRs based on father-son pair data.
Evaluation of facial hair-associated SNPs: a pilot study on male Pakistani Punjabi population.
Forensic Sci Med Pathol
September 2023
Article Synopsis
- The study investigates the genetic basis of facial hair traits in Punjabi males from Pakistan by examining 16 specific genetic variations (SNPs) that may influence features like monobrows, eyebrow thickness, and beard thickness.
- Significant associations were found for particular SNPs: rs365060 in EDAR and rs12597422 in FTO related to monobrows, rs6684877 in MACF1 linked to eyebrow thickness, and rs9654415 and rs7702331 in LOC105379031 connected to beard thickness.
- The findings highlight potential differences in genetic associations for facial hair traits across different ethnic groups and regions, suggesting further research is needed for validation but having implications for forensic studies
Article Synopsis
- Tibetans, living primarily in high-altitude regions of China and the Himalayas, exhibit unique genetic traits that help them adapt to low oxygen levels, making them interesting for medical and genetic research.
- A study genotyped 549 individuals using the Investigator Argus X-12 Kit, discovering 174 unique alleles and finding that specific loci (DXS10134 and DXS10135) showed significant variation.
- The analysis revealed a high diversity of haplotypes among Highlander Tibetan males and established strong discrimination power for both genders, providing valuable data for forensic and population genetic studies.
Background: Xibe is the fifth largest minority population of Liaoning province. Predominately they live in Liaoning province (69.52%), followed by Xinjiang (18.
View Article and Find Full Text PDFArticle Synopsis
- Gypsies, also known as Roma or untouchables, are a distinct ethnic group in Pakistan, characterized by their nomadic lifestyle and unique living conditions in tent houses.
- A study on 285 unrelated Roma individuals in Punjab used genetic analysis to reveal high allelic diversity and demonstrated a close genetic relationship between Pakistani Roma and those from Romania.
- The research indicated significant gene flow and historical migration patterns from Pakistan to India and Europe, showcasing the marked genetic diversity within the Roma population.
Article Synopsis
- The Xinjiang Uyghur Autonomous Region in China is home to nearly 50 ethnic groups, with the majority being Uyghur, Han, Kazakh, and Hui, representing 97.33% of the population.
- In a study, researchers analyzed genetic data from 2,121 samples across these four major ethnic groups, using advanced STR analysis techniques, revealing various genetic diversity metrics.
- The genetic findings highlighted distinct affinity and relationships among populations based on linguistic, ethnic, and geographical contexts, with no significant departures from Hardy-Weinberg equilibrium observed.
Article Synopsis
- Human teeth, especially carious ones, are emerging as valuable sources for forensic DNA due to their resistance to harsh conditions.
- This study compared two methods for extracting DNA from carious teeth, the operative technique and the cervical cut technique, focusing on their effectiveness for human identification.
- Results showed that both techniques were reliable, but the operative technique was more efficient, cost-effective, and less invasive for DNA recovery.
Article Synopsis
- - The Hazara population, linked to Genghis Khan's army and characterized by Mongolian features, has a rich history of interaction with Central and East Asian groups, while the Baloch are associated with the Balochi language.
- - A comprehensive genetic study involving 260 Hazara individuals from Afghanistan and 153 from Pakistan, alongside 111 Balochi individuals from Baluchistan, utilized Yfiler Plus PCR to analyze Y-STR loci, revealing significant diversity with 380 different haplotypes.
- - Findings showed that the Yfiler Plus kit offered enhanced discriminatory power for genetic differentiation within Baloch and Hazara populations, as evidenced by various genetic distance analyses and other methods, highlighting their unique genetic
Article Synopsis
- The article has been removed from publication at the request of the author(s) or editor.
- The publisher has apologized for any inconvenience caused by this withdrawal.
- For more details, you can refer to Elsevier's official policy on article withdrawal.
Article Synopsis
- The Tibetan Empire's expansion from the 7th to 9th centuries significantly influenced East Eurasian history, yet its genetic effects on nearby populations were not well understood.* -
- Researchers sequenced genomes from populations in Pakistan and Tajikistan, finding that the Balti people have 22.6-26% Tibetan ancestry, linked to a single admixture event around 39-21 generations ago.* -
- The study concludes that while the Balti adopted Tibetan language and culture, the genetic influence from Tibet was mainly cultural rather than significant population movement, highlighting both male and female contributions in this change.*
Article Synopsis
- - The study compared three fixation methods for posterior malleolar fractures (PMFs) using human cadaveric ankles and finite element analysis to determine which method provides the best stability.
- - Group-A was fixed with anteroposterior lag screws, group-B with posteroanterior lag screws, and group-C used a posterior plate, with results showing that the plate group required significantly higher loads to achieve the same displacement as the screw groups.
- - Findings indicated that posterior plating offers superior biomechanical stability with the lowest stress and fracture step-off compared to the lag screw methods, making it the preferable choice for PMFs fixation.
Article Synopsis
- Background and Purpose
- : The study focuses on microsatellites (STRs) as critical tools for forensic identification, aiming to develop a comprehensive population database using an extensive set of 20 autosomal STRs.
- Methodology
- : Researchers analyzed the genetic attributes of 20 STR loci in 1,138 unrelated Han individuals from Liaoning using a specific amplification kit and conducted a phylogenetic analysis to compare with other populations.
- Findings and Implications
- : The study found 253 alleles with extremely high discrimination and exclusion powers, indicating the diversity of the Han population, while also showing that they are genetically distinct from minority populations in Xinjiang, making these STRs suitable for forensic
Background: In China, most Koreans live in the Northeast, including Jilin (59.64%), Heilongjiang (20.21%), and Liaoning (12.
View Article and Find Full Text PDFArticle Synopsis
- - China has a diverse population of over 1.4 billion people, primarily consisting of the Han ethnic group (93%), making it the most populous country in the world.
- - This study provides the first genetic data on Y-chromosomal short tandem repeats (YSTRs) from 270 Han individuals in Anshan City, revealing 170 alleles and high haplotype diversity, indicating a distinct genetic structure compared to minority groups like Tibetans and Kazakhs.
- - The findings suggest that the Goldeneye 20Y system has strong discriminatory power in this population, making it valuable for forensic applications within the Han ethnic group in China.
Article Synopsis
- The FUT3 gene is crucial for producing Lewis fucosyltransferase, which impacts the Lewis phenotype relevant to both clinical and legal contexts.
- This study identified 23 point mutations in the FUT3 gene among Sindhi and Punjabi populations, including 7 novel mutations, with some mutations predicted to diminish enzyme activity.
- The research found that Lewis-negative phenotypic frequencies were notably present in both ethnic groups, indicating a significant genetic diversity and Caucasian traits in the FUT3 gene among these Pakistani populations.