First case report on Bickerstaff brainstem encephalitis in a young adult from Syria: Bridging clinical knowledge and practice.

Bickerstaff Brainstem Encephalitis (BBE) is a rare immunologic condition characterized by CNS inflammation, presenting with ataxia, external ophthalmoplegia, altered consciousness, and quadriplegia. A 25-year-old male with no significant medical history exhibited symptoms of blurred vision, diplopia, facial numbness, and imbalance following a respiratory infection. Brain MRI revealed hyperintense lesions in the cerebral peduncle and pons on T2-weighted/FLAIR sequences but not on T1-weighted sequences, indicative of demyelination.

Rehabilitation of N, N'-methylenebisacrylamide-induced DNA destruction in the testis of adult rats by adipose-derived mesenchymal stem cells and conditional medium.

Environmental pollutant acrylamide has toxic effect on human health. Numerous industries such as the paper, and cosmetics, use acrylamide in their manufacturing. In certain foods, acrylamide arises at extremely high temperatures.

Carob fruit extract as naturally products corrosion inhibitor for copper-nickel alloys in brine solutions.

Copper-nickel alloys are the preferred material for desalination facilities and condensers and heat exchangers that use saltwater as a coolant. The eco-friendly compounds especially Carob fruit extract (CFE) has emerged as excessive green corrosion inhibitor for alloys. Cu-Ni alloys are widely used in various industries due to their excellent corrosion resistance.

The cytotoxic activities of the major diterpene extracted from Salvia multicaulis (Bardakosh) are mediated by the regulation of heat-shock response and fatty acid metabolism pathways in human leukemia cells.

Background: Leukemia is one of the most lethal cancers worldwide and represents the sixth-leading cause of cancer deaths. The results of leukemia treatment have not been as positive as desired, and recurrence is common.

Purpose: Thus, there is an urgent requirement for the development of new therapeutic drugs.

Verbena officinalis (VO) leaf extract as an anti-corrosion inhibitor for carbon steel in acidic environment.

In the present work, Verbena Officinalis (VO) leaf extract was used as potential corrosion inhibitor for the corrosion of carbon steel (CS) in 0.5 M HSO medium. Further, the corrosion inhibiting nature of VO leaf extract towards the CS was evaluated using mass loss (ML), potentiodynamic polarization (PDP), electrical impedance spectroscopy (EIS) and surface morphological analyses using atomic force microscope (AFM) and X-ray photoelectron spectroscopy (XPS) techniques.

Methamphetamine detection using portable capillary electrophoresis coupled with a swab-based extraction device.

Methamphetamine (MA) is one of the most virulent illicit drugs that can be synthesized from household materials leading to its prevalent trafficking and local manufacturing in clandestine drug laboratories (clan labs). The significant problems of tracing MA in clan labs and monitoring drug abusers lie in the lag time between sample collection and analysis and the number of tests done. Capillary electrophoresis (CE) is a rapid separation technique amenable to miniaturization and field testing.

Pathological Characterization and Management of , a Hemibiotroph with an Interkingdom Host Range.

Heart rot disease, caused by , is destructive for date palms and other woody plants. The disease was reported in several oases in Egypt, and the pathogen was found in association with infected trees suffering dieback and rachis blight. Seven phylogenetically distinct fungal isolates were selected, and their pathogenicity was confirmed on date palms.

Carcinoma in situ within the bladder trigone with an isolated metastasis to the prostate without involvement of prostatic urethra: a unique case report.

Background: Carcinoma in situ of the bladder is a high-grade cancer that originates in the superficial layer of the bladder. It has the potential to invade nearby organs, and it can spread through blood and lymphatic circulation to distant parts of the body.

Case Presentation: A 58-year-old non-smoker male presented with gross and microscopic hematuria.

Nanoparticles and Chemical Inducers: A Sustainable Shield against Onion White Rot.

This study investigated the effectiveness of nanoparticles and chemical inducers in managing onion white rot caused by . The pathogen severely threatens onion cultivation, resulting in significant yield losses and economic setbacks. Traditional fungicides, though effective, raise environmental concerns, prompting a shift toward eco-friendly alternatives.

Crop bioengineering via gene editing: reshaping the future of agriculture.

Genome-editing technologies have revolutionized research in plant biology, with major implications for agriculture and worldwide food security, particularly in the face of challenges such as climate change and increasing human populations. Among these technologies, clustered regularly interspaced short palindromic repeats [CRISPR]-CRISPR-associated protein [Cas] systems are now widely used for editing crop plant genomes. In this review, we provide an overview of CRISPR-Cas technology and its most significant applications for improving crop sustainability.

A comprehensive survey of warfarin-induced hepatic toxicity using histopathological, biomarker, and molecular evaluation.

Warfarin finds human application as anticoagulant therapy. Warfarin usage can cause liver damage and hemorrhage. Besides functioning as anticoagulant and causing continuous bleeding of pests, the mechanism of toxicity of warfarin is unknown.

Argel's stemmoside C as a novel natural remedy for mice with alcohol-induced gastric ulcer based on its molecular mechanistic pathways.

Ethnopharmacological Relevance: Solenostemma argel is widely distributed in Africa & Asia with traditional usage in alleviating abdominal colic, aches, & cramps. This plant is rich in phytochemicals, which must be explored for its pharmacological effects.

Purpose: Peptic Ulcer Disease (PUD) is the digestion of the digestive tube.

Differential impacts of interactions between Serendipita indica, Chlorella vulgaris, Ulva lactuca and Padina pavonica on Basil (Ocimum basilicumL.).

Plant biostimulants (PBs) are used globally to increase crop yield and productivity. PBs such as (Serendipita indica) or algal extracts stimulate and accelerate plant physiological processes. The physiological, ecological, and biochemical effects of (Serendipita indica) or algal extracts individually and in combination on basil plant (Ocimum basilicum L.

Chemical vapour deposition in narrow capillaries: Electro-osmotic flow control in capillary electrophoresis.

Background: In capillary electrophoresis (CE), the inner surface of fused-silica capillaries is commonly covalently modified with liquid silanes to control electroosmotic flow (EOF). This liquid phase deposition (LPD) approach is challenging for long and narrow-diameter capillaries (≥1 m, ≤25 μm ID) inhibiting commercial production. Here, we use chemical vapour deposition (CVD) to covalently modify capillaries with different silanes.

Novel porphyrin derivatives as corrosion inhibitors for stainless steel 304 in acidic environment: synthesis, electrochemical and quantum calculation studies.

A Novel 5,10,15,20-tetra (thiophen-2-yl) porphyrin (P1) and 5,10,15,20-tetrakis (5-Bromothiophen-2-yl) porphyrin (P2) were successfully synthesized, and their chemical structures were proved based on its correct elemental analysis and spectral data (IR and H-NMR). These compounds were examined as corrosion inhibitors for stainless steel 304 (SS304) in 2 M HCl utilizing mass reduction (MR) and electrochemical tests at inhibitor concentration (1 × 10-21 × 10 M). The protection efficiency (IE %) was effectively enhanced with improving the concentration of investigated compounds and reached 92.

Driving risk cognition of passengers in highly automated driving based on the prefrontal cortex activity via fNIRS.

For high-level automated vehicles, the human being acts as the passenger instead of the driver and does not need to operate vehicles, it makes the brain-computer interface system of high-level automated vehicles depend on the brain state of passengers rather than that of drivers. Particularly when confronting challenging driving situations, how to implement the mental states of passengers into safe driving is a vital choice in the future. Quantifying the cognition of the driving risk of the passenger is a basic step in achieving this goal.

Assessing the Effectiveness of Eco-Friendly Management Approaches for Controlling Wheat Yellow Rust and Their Impact on Antioxidant Enzymes.

Wheat stripe rust, caused by f. sp. (), is a destructive disease that causes significant yield losses in wheat production worldwide, including in Egypt.

Potential drug candidates as P-glycoprotein inhibitors to reverse multidrug resistance in cancer: an drug discovery study.

The failure of chemotherapy in the treatment of carcinoma is mainly due to the development of multidrug resistance (MDR), which is largely caused by the overexpression of P-glycoprotein (P-gp/ABCB1/MDR1). Until recently, the 3D structure of the P-gp transporter has not been experimentally resolved, which restricted the discovery of prospective P-gp inhibitors utilizing techniques. In this study, the binding energies of 512 drug candidates in clinical or investigational stages were assessed as potential P-gp inhibitors employing methods.

Development of rapid and precise approach for quantification of bacterial taxa correlated with soil health.

The structure and dynamic of soil bacterial community play a crucial role in soil health and plant productivity. However, there is a gap in studying the un-/or reclaimed soil bacteriome and its impact on future plant performance. The 16S metagenomic analysis is expensive and utilize sophisticated pipelines, making it unfavorable for researchers.

Portable capillary electrophoresis coupled with swab-based extraction device for cleaning validation in pharmaceutical facilities.

All pharmaceutical manufacturers are required to verify that their production equipment is free from contaminants. Here, we report the capability of a fully automated portable capillary electrophoresis instrument with an integrated sample swab extraction - the Grey Scan ETD-100 - for the detection of pharmaceutical residues on surfaces of manufacturing equipment. Lidocaine was used as a model compound and could be recovered from a surface by swabbing, extracted from the swab, and analysed within 1 min.

A new cembranoid from the Red Sea soft coral .

The Red Sea soft coral ethyl acetate extract has afforded one new cembranoid; sarcacutumolid A (), along with six known metabolites have been isolated from for the first time (). Chemical structures were elucidated by employing several spectroscopic analyses. The cytotoxic potential of the isolated compounds was assessed against four human cancer cell lines; hepatocellular (HepG2), cervical (HeLa), breast (MCF-7) and colorectal cancer (Colo-205).

Reconfigurable Soft Robots by Building Blocks.

Soft robots are of increasing interest as they can cope with challenges that are poorly addressed by conventional rigid-body robots (e.g., limited flexibility).

Immune hyporeactivity to bacteria and multiple TLR-ligands, yet no response to checkpoint inhibition in patients just after meeting Sepsis-3 criteria.

Rationale: The immune profile of sepsis patients is incompletely understood and hyperinflammation and hypoinflammation may occur concurrently or sequentially. Immune checkpoint inhibition (ICI) may counter hypoinflammation but effects are uncertain. We tested the reactivity of septic whole blood to bacteria, Toll-like receptor (TLR) ligands and to ICI.

Anti-androgenic potential of the fruit extracts of certain Egyptian species and their genetic variability studies: a metabolomic-molecular modeling approach.

This work aimed to evaluate the anti-androgenic activity of Glazebrook, (O. F. Cook) Becc, and (Walter) Lodd.