Publications by authors named "Athula Dissanayake"
The inherited disease community in Sri Lanka has been widely neglected. This article aimed to present accumulated knowledge in establishing a pro bono cost-effective national, island-wide, free-of-charge molecular diagnostic service, suggesting a model for other developing countries. The project provided 637 molecular diagnostic tests and reports free of charge to a nation with limited resources.
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- - The study analyzed genetic mutation data from patients in Sri Lanka with Duchenne muscular dystrophy (DMD), spinal muscular atrophy (SMA), spinocerebellar ataxia (SCA), and Huntington's disease (HD) to identify candidates for gene therapy, comparing results with literature from India and Pakistan.
- - A total of 623 rare disease patients were tested for molecular diagnostics using MLPA and single plex PCR, with 343 (55%) testing positive, revealing significant numbers of patients suitable for gene therapy options.
- - The authors identified 147 Sri Lankan patients eligible for existing gene therapy and found a combined total of 1257 patients from Sri Lanka, India, and Pakistan, while noting that most
Background: Stroke is a heterogeneous, catastrophic disease. A comprehensive clinical analysis of ischemic stroke (IS) risk factors and outcomes is crucial for optimum management in resource-poor settings.
Methods: A prospective cross-sectional study of acute cerebrovascular disease (ACVD) involving 592 patients was conducted in a tertiary care center in Sri Lanka from November 2018 to May 2019.
Background: Progressive neurological genetic diseases are not rare. They cause psychosocial damages to its victims. This article focuses on common psychosocial issues faced by those from the developing world.
View Article and Find Full Text PDFWe describe a 36-year-old man with subacute sclerosing panencephalitis (SSPE) presenting with chorioretinitis two years before onset of other neurological features. He had neither myoclonus nor the typical EEG features of SSPE. The diagnosis was confirmed in the appropriate clinical setting by detecting elevated measles antibody titres in cerebrospinal fluid and serum.
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