Publications by authors named "Athul Mohan"

We integrate machine learning approaches with nonlinear time series analysis, specifically utilizing recurrence measures to classify various dynamical states emerging from time series. We implement three machine learning algorithms: Logistic Regression, Random Forest, and Support Vector Machine for this study. The input features are derived from the recurrence quantification of nonlinear time series and characteristic measures of the corresponding recurrence networks.

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Perineurioma is a rare benign soft tissue tumor arising from the peripheral nerve sheath. To date only two cases of orbital perineurioma have been reported in literature. A 45-year-old, with no comorbidities, presented with protrusion of the right eye since one-year.

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MicroRNA-10b (miR-10b) is a unique oncogenic miRNA that is highly expressed in all GBM subtypes, while absent in normal neuroglial cells of the brain. miR-10b inhibition strongly impairs proliferation and survival of cultured glioma cells, including glioma-initiating stem-like cells (GSC). Although several miR-10b targets have been identified previously, the common mechanism conferring the miR-10b-sustained viability of GSC is unknown.

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Article Synopsis
  • Researchers analyzed The Cancer Genome Atlas data to find microRNAs linked to glioblastoma (GBM) survival, pinpointing miR-148a and miR-31 as key players in tumor growth.
  • * In mouse models, blocking these microRNAs led to decreased tumor size and increased survival rates, indicating their role in cancer progression.
  • * The study reveals that miR-148a and miR-31 contribute to glioma growth by influencing tumor stem cells and enabling blood vessel formation, even in normal oxygen conditions, highlighting a novel therapeutic approach using antagomirs.
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Synopsis of recent research by authors named "Athul Mohan"

  • - Athul Mohan's recent research encompasses diverse fields, including machine learning applications for time series analysis, rare tumor case studies, and innovative cancer therapies targeting microRNAs.
  • - In the study on machine learning, Mohan successfully implemented algorithms like Logistic Regression, Random Forest, and Support Vector Machine to classify dynamical states from recurrence measures in nonlinear time series.
  • - His cancer-related research highlights the oncogenic role of microRNA-10b in glioblastoma and utilizes The Cancer Genome Atlas to identify specific microRNAs that could be targeted to control tumor growth and enhance therapy efficacy.